Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease.

Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease. Biosci Rep. 2019 Jul 12;: Authors: Ray U, Bank S, Jayawardana M, Bhowmik J, Redwig F, Jana P, Bhattacharya S, Manna E, De SK, Maiti S, Roberts-Thompson PP, Parameswaran V, Sinha AK Abstract Lack of insulin or insulin resistance (IR) plays a central role in diabetes mellitus and makes diabetics prone to acute ischemic heart disease (AIHD). It has likewise been found that many cancer patients, including prostate cancer patients die of AIHD. Previously it has been delineated from our laboratory that dermcidin could induce anomalous platelet aggregation in AIHD and also impaired nitric oxide and insulin activity and furthermore dermcidin was also found in a few types of cancer patients. To determine the role of this protein in prostatic malignancy a retrospective case-control study was conducted and blood was collected from prostate cancer patients and healthy normal volunteers. So, we measured the level of dermcidin protein and analyze the IR by HOMA score calculation. Nitric oxide was measured by methemoglobin method. HDL, HbA1c, BMI, hs-cTroponin-T were measured for the validation of the patients' status in the presence of DCN-2. Multiple logistic regression model adjusted for age and BMI identified that the Homeostasis Model Assessment (HOMA) score was significantly elevated in prostate cancer patients (OR=7.19, p
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research

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