Inflammatory Myofibroblastic Tumor of Bone Harboring an ALKGene Amplification

Publication date: Available online 13 July 2019Source: Pathology - Research and PracticeAuthor(s): Kai Wang, Rongjun Guo, Gene P Siegal, Shi WeiAbstractInflammatory myofibroblastic tumor (IMT) is a neoplastic proliferation of myofibroblastic/fibroblastic cells with a variable admixture of inflammatory cells. It primarily affects soft tissue and viscera of children and young adults. IMT occurring in bone is extremely rare. Approximately 50% of IMTs carry a clonal rearrangement of the anaplastic lymphoma kinase (ALK) gene, while other receptor tyrosine kinase gene rearrangements have been seen in a small subset of IMT. Herein, we report the first case of IMT which harbors an ALK gene amplification rather than a rearrangement thus resulting in overexpression of the protein, arising from the femur of a 24-year-old man. Our case provides a novel pathogenesis for IMT. An overview of cytogenetic abnormalities of IMT is also integrated into this report.
Source: Pathology Research and Practice - Category: Pathology Source Type: research