Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain Pathologies
This cohort study examines the association of lifespan cognitive reserve with dementia risk.
Kerrin Kuhn today is the executive director of the Alzheimer ’s&Dementia Resource Center (ADRC), but when she was taking care of her mother, who suffered from Alzheimer ’s, Kuhn had no idea the nonprofit was in the same metro where she lived. Kuhn’s mother died 6 years ago, and it’s only after joining the Altamonte Springs-based organization that Kuhn realized how it could have helped her and her family. That realization makes her all the more passionate t o help the Central Floridians…
This study describes the organization, implementation, and evaluation of an intervention for underserve...
A study from Massachusetts General Hospital used an artificial intelligence model to assess the difference between a person's actual age and the biological age of their brain.
Conditions: Mild Cognitive Impairment; Alzheimer Disease; Vascular Dementia Intervention: Diagnostic Test: Retinal fundus photography Sponsors: Mayo Clinic; Eyenuk, Inc.; Malavika Bhaskaranand PhD; Kaushal Solanki Recruiting
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DEMENTIA is a progressive brain condition so symptoms get steadily worse over time. The type of symptoms a person experiences is determined by their specific form of dementia. A sign in your sense of smell may signal dementia with Lewy bodies.
This document takes the wellbeing pathway and sets out the adjustments and amendments needed to respond to the COVID-19 pandemic. It highlights key priorities and actions for each step in the pathway.
Disrupting pathogenic variants in RNA-binding proteins such as TDP-43, hnRNPA2B1, FUS, TIA-1 are known to cause a spectrum of diseases, including frontotemporal dementia, amyotrophic lateral sclerosis, inclusion body myopathy, and/or distal myopathy. Using deep clinical phenotyping and exome sequencing, we identified six unrelated families all with a distinct class of dominantly-acting heterozygous variants in hnRNPA2B1 with a unique clinical phenotype of early childhood-onset progressive muscle weakness, ophthalmoplegia, ptosis, dysphagia, and variable degrees of respiratory insufficiency but no dementia.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative conditions with shared genetic susceptibility and a large portion of familial cases due to c9orf72 gene mutations. Brain imaging studies in asymptomatic c9orf72 carriers have demonstrated white (WM) and grey matter (GM) degeneration before the age of 40. The aim of this study was to investigate whether cervical spinal cord (SC) degeneration can be detected in asymptomatic c9orf72 hexanucleotide carriers using multimodal quantitative imaging.
A woman describes her pain at not being able to see her husband regularly at his care home.