Antimicrobial and antibiofilm activities of prenylated flavanones from Macaranga tanarius

ConclusionThese findings show that prenylated flavanones, especially propolin D from Macaranga tanarius (Okinawan propolis), should be considered potential candidates for the development of non-toxic antibacterial and antifungal agents against persistent microorganisms.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research

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This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges o...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, it was suggested that L. tigrinus can be used as a natural source due to its antioxidant and antimicrobial activities. PMID: 30515206 [PubMed]
Source: Advances in Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
In conclusion, OG Ag+ was shown to be an effective wound dressing in the killing of a range of important opportunistic pathogens of relevance to wound healing and infections. Achieving a six log kill against S. aureus and E.coli, within 16 hours in the time kill assay, (ASTM E2315-03) demonstrates that OG Ag+ should be an important addition to the armoury available for the management of acute and chronic wounds at risk of infection or clinically infected. PMID: 29529703 [PubMed - as supplied by publisher]
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
Conclusion The incidences of VAP, CAUTI, and CLABSI were high in ICUs, and multidrug-resistant organisms were the primary pathogens of NI. The implementation of targeted surveillance may determine the risk factors of NI so that effective intervention measures can be taken to reduce the incidence of NI in ICU patients.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
CONCLUSIONS Escherichia coli and MRSA are major pathogens of medical device-related infections.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
CONCLUSION: A small library of heterocyclic-containing chalcones was developed and initial screening demonstrates modest activity against cancers, bacteria, and fungi. PMID: 29065840 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research
Conclusions The incidence of VAP, CAUTI, and CLABSI were high in ICUs, and multi-drug resistant organisms were the primary pathogens of NI. The implementation of targeted surveillance can determine the risk factors of NI so that effective intervention measures can be taken to reduce the incidence of NI in ICUs patients.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
T2 Biosystems Inc. (NSDQ:TTOO) said today it filed a 510(k) appliation with the FDA for its T2Bateria Panel rapid diagnostic solution designed to identify pathogens assocaited with Sepsis. The T2Bacteria panel is designed to run on the FDA-cleared T2Dx instrument to provide diagnosis of sepsis pathogens within hours, reducing the time for patients with bloodstream infections to receive treatment, the Lexington, Mass.-based company said. The submission includes data from a pivotal clinical trial of the T2Bacteria Panel which compared it to blood culture, as well as the performance of the panel in known bacteria positiv...
Source: Mass Device - Category: Medical Devices Authors: Tags: Diagnostics Food & Drug Administration (FDA) Regulatory/Compliance T2 Biosystems Inc. Source Type: news
Conclusions/implications While bismuth subsalicylate, and bismuth tribromophenate unbound to Xeroform® demonstrate antimicrobial activity, it appears that Xeroform® dressings do not. The utility of Xeroform® in burn medicine may relate more to use as an impervious dressing than to antimicrobial effect. Donor sites are clean surgical wounds and clean partial thickness burns may have minimal colonization present. In such circumstances, an inactive and impervious dressing may be all that is necessary to promote wound healing. Graphical abstract
Source: Burns - Category: Dermatology Source Type: research
Abstract The rapid, broad-spectrum, biofilm eradicating activity of the combination 0.01% nitroglycerin, 7% citrate and 20% ethanol and its potential as a non-antibiotic, antimicrobial catheter lock solution (ACLS) was previously reported. Here a Nitroglycerin-Citrate-Ethanol (NiCE) ACLS optimized for clinical assessment was developed by reducing nitroglycerin and citrate concentrations and increasing ethanol concentration. Biofilm eradicating activity was sustained when the ethanol concentration was increased from 20 to 22% and fully compensated for reducing the citrate concentration from 7% to 4% as well as the ...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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