A novel LGI1 missense mutation causes dysfunction in cortical neuronal migration and seizures.

CONCLUSION: Our findings enrich the spectrum of LGI1 mutations and support the pathogenicity of the mutation. Furthermore, additional information regarding the role of LGI1 in the development of temporal lobe epilepsy was elucidated, and a potential relationship was established between cortical neuronal migration dysfunction and autosomal dominant partial epilepsy with auditory features. PMID: 31301272 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31301272?dopt=Abstract

Source: Brain Research - July 9, 2019 Category: Neurology Authors: Liu F, Du C, Tian X, Ma Y, Zhao B, Yan Y, Lin Z, Lin P, Zhou R, Wang X Tags: Brain Res Source Type: research