Chronic myelomonocytic leukemia with ETV6-ABL1 rearrangement and SMC1A mutation

We report a patient who had a clinical and morphological presentation consistent with CMML. The genetic work-up showed an ETV6-ABL1 fusion consequent to a 9;12 translocation, and a missense mutation in SMC1A (c.1757G>A, p.Arg586Gln).

Source: Cancer Genetics and Cytogenetics - July 12, 2019 Category: Genetics & Stem Cells Authors: Melissa H. Cessna, Prabakaran Paulraj, Benjamin Hilton, Kianoush Sadre-Bazzaz, Philippe Szankasi, Alice Cluff, Jay L. Patel, Daanish Hoda, Reha M. Toydemir Tags: Case Report Source Type: research