Targeting TGF β pathway in Adult Granulosa Cell Tumor: Opening Pandora's Box?

Targeting TGFβ pathway in Adult Granulosa Cell Tumor: Opening Pandora's Box? Clin Cancer Res. 2019 Jul 11;: Authors: Bonilla L, Oza AM Abstract Adult granulosa cell tumor (AGCT) is a rare malignancy characterized by FOXL2 (C134W) mutation, an inherent component of the TGFβ pathway. Activin A, a TGFβ superfamily member, is a driver of this activity and is a potential target in AGCT. PMID: 31296528 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research