The novel inhibitor PRI-724 for Wnt/ β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice.

Conclusions: These results suggest that the β-catenin/CBP inhibitor PRI-724 is a potent antifibrotic agent that acts by modulating the activity of macrophages in the lungs. PMID: 31298961 [PubMed - as supplied by publisher]
Source: Experimental Lung Research - Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research