Synthesis & characterization of biologically active Gigantic swallow-wort mediated silver nanoparticles
Publication date: Available online 12 July 2019Source: Materials Today: ProceedingsAuthor(s): U. Nagababu, B. Govindh, B.S. Diwakar, G. Kiran Kumar, Anindita ChatterjeeAbstractSilver (Ag) nanoparticles (NPs) were produced by a simple, one step green method using Gigantic swallow-wort leaf aqueous extract. Intrinsic structural and physiochemical properties of Ag NPs were investigated and demonstrated their applicability in biomedicine. The IR data revealed the capping of organic molecules from plant extract. Further, the fluorescence studies were carried and found the molecules exhibit excitation at 400 nm. The biological studies demonstrate that these Ag NPs exhibit the good to excellent anti-bacterial character against Klebsiella pneumonia and E. coli.
CONCLUSIONS: Hospital-acquired pneumonia is more likely correlated with ESBL-producing E. coli and K. pneumoniae. ESBL-producing E. coli ST131 and multi-drug resistance ESBL-producing, as well as New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemases-2 (KPC-2) bearing K. pneumoniae ST11 are spreading in patients with pneumonia in hospital. PMID: 31408445 [PubMed - in process]
;r SA Abstract Empiric antibiotic therapy with a betalactam is standard of care in febrile neutropenia (FN), and is given to prevent early death. The addition of vancomycin is recommended in certain circumstances but the quality of evidence is low, reflecting the lack of clinical data. In order to characterize the epidemiology of early death and shock in FN, we reviewed all episodes of FN from 2003 to 2017 at University Hospital, Federal University of Rio de Janeiro, and looked at factors associated with shock at first fever and early death (within 3 days from first fever) by univariate and multivariate analyses. ...
ConclusionThe present study revealed that Enterobacteriaceae in wastewater from hospitals, abattoir and downstream water bodies are resistant to commonly used antimicrobials. Hospital effluents contained more of MDR bacteria, posing significant public health threat through dissemination to the downstream water bodies.
Conclusions: EVs induced and released during severe bacterial pneumonia were inflammatory and induced ALI, and HMW HA administration was effective in inhibiting the uptake of EVs by target cells and decreasing lung injury from E.coli EVs or bacterial pneumonia. PMID: 31390880 [PubMed - as supplied by publisher]
This study reports on the preparation and in vitro antibacterial activity and cytotoxicity determination of ciprofloxacin loaded chitosan (Cipro-CS) microparticles with size in the range of 0.1-1 µm, which may provide advantages of lower nanotoxicity and lower local clearance. Cipro-CS microparticles were prepared by ionic gelation method and their size, zeta potential and drug release pattern determined. The antibacterial activities of CS and Cipro-CS microparticles against pneumonia causing agents, namely Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, were evaluated by determination of minimum ...
ConclusionTo our knowledge, this study is the first to report anE. coli ST167 strain co-producing NDM-5, CTX-M-14, OXA-10 and MCR-1 isolated from a sputum sample of an individual with pneumonia in Japan, thus elucidating the molecular characteristics and resistance gene diversity of this strain.
Pneumonia and sepsis are distinct but integrally linked public health concerns. The hepatic acute-phase response (APR), which is largely dependent on transcription factors NF-B RelA and STAT3, is a hallmark of these pathologies and other injurious conditions. Inactivation of the APR can promote liver injury, a frequently observed organ dysfunction during sepsis. However, whether or how the acute-phase changes promote liver tissue resilience during infections is unclear. To determine the hepatoprotective role of the hepatic APR, we utilized mice bearing hepatocyte-specific deletions of either RelA or STAT3. Mice were challe...
In this study, we found the AgNPs effectively induces cytotoxicity, ROS and apoptosis by modulation of intrinsic apoptoic Bcl2, Bclxl, Bax and Caspase 3 protein expressions in LNCap cell lines. Based on the study, synthesis of AgNPs from S. miltiorrhiza shows eco-friendly and it exhibits antimicrobial and anticarcinogenic effects. PMID: 31299869 [PubMed - in process]
Authors: Vachvanichsanong P, McNeil E, Dissaneewate P Abstract OBJECTIVES: We set out to determine the causes of death in childhood-onset systemic lupus erythematosus (cSLE). METHODS: The medical records of children aged
ConclusionsTo our knowledge, this study is the first to report an E.coli ST167 strain co-producing NDM-5, CTX-M-14, OXA-10, and mcr-1, isolated from sputum samples of individuals with pneumonia in Japan, thus elucidating the molecular characteristics and resistance gene diversity of this strain.