Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease.

CONCLUSION: PD carriers of GBA variants are at high risk for cognitive decline and depression. Screening for these variants may facilitate early identification, and effective management of these non-motor symptoms. The molecular mechanisms underlying favourable cognitive functioning in LRRK2 rs34637584 variant carriers warrant further investigation. PMID: 31292011 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research