The effect of AP-2 δ on transcription of the Prestin gene in HEI-OC1 cells upon oxidative stress.

Conclusions: In conclusion, oxidative stress inhibits the expression of Prestin protein, and the transcription mechanism is triggered to compensate for the loss of Prestin protein. AP-2δ is one of the important TFs that suppresses transcription of the Prestin gene, and AP-2δ suppression further boosted Prestin mRNA activation under oxidative stress. PMID: 31297132 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Cell Mol Biol Lett Source Type: research