Mycophenolate mofetil and atopic dermatitis: systematic review and meta-analysis.

Conclusions: In summary, the current evidence to date is low-quality in nature but is promising regarding the efficacy and safety of MMF for adult and paediatric atopic dermatitis. There should be ongoing monitoring for infections that may develop on long term therapy. PMID: 31294617 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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We report a novel case of facial erythema in a patient treated with dupilumab.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Conditions:   Atopic Dermatitis With a History of Eczema Herpeticum;   Atopic Dermatitis Without a History of Eczema Herpeticum;   Health Controls Without Atopy Intervention:   Biological: Xolair Sponsors:   National Jewish Health;   Genentech, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract: Dermatitis herpetiformis is a rare, chronic autoimmune disorder characterized by intense pruritic papules and vesicles, which can be associated with celiac disease and other autoimmune disorders. Its histologic characteristic is the accumulation of neutrophils within the papillary dermis with granular deposition of immunoglobulin A (IgA) observed under direct immunofluorescence. Herein, we report a 58-year-old woman who presented with a vesicular rash on the buttocks. The patient reported a recent history of genital herpes, Entamoeba histolytica colitis, recurrent hives, and eczema. A representative biopsy demo...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
We present four clinicopathological correlated cases of young patients with cryothermic dermatitis artefacta. They were initially misdiagnosed as primary bullous dermatoses or fixed drug eruptions. Cryothermic dermatitis artefacta can imitate authentic dermatoses such as linear IgA bullous dermatosis, herpes virus infection, bullous pemphigoid or fixed drug eruption. It should be considered as differential diagnosis in uncommon cases of recurrent bullae in adolescent and young adult patients. We summarize helpful clinical and histopathological criteria for correct diagnosis and therewith causative treatment. PMID: 3117...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
CONCLUSION: Dupilumab treatment in daily practice shows a clinically relevant improvement of physician-reported scores and PROMs, which is in line with efficacy data from clinical trials. Besides frequently reported eye symptoms and orofacial (non-ocular) HSV reactivation, there were no apparent safety concerns. This article is protected by copyright. All rights reserved. PMID: 31145810 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Red, itchy and inflamed skin is a well-known symptom of what's generally called eczema. While there are a variety of conditions described in this way, the most common type of eczema is atopic dermatitis. Occasionally, complications develop and the skin becomes infected. When this happens, there are a number of treatment options available. Consult your doctor or medical practitioner if you have any questions regarding your eczema treatment plan, but in the meantime, here are some things you'll want to know about the condition. When eczema becomes infected, there are a variety of treatments.  What causes an ec...
Source: Advanced Tissue - Category: Dermatology Authors: Tags: Wound Care Wound Infection Source Type: news
AbstractBackgroundPatients with moderate-to-severe atopic dermatitis (AD) have increased infection risk, including skin infections and systemic infections. Immunomodulators (e.g., anti-tumor necrosis factors, anti-interleukin [anti-IL]-23, anti-IL-17, Janus kinase inhibitors) increase risk of infections. Dupilumab (a monoclonal antibody blocking the shared receptor component for IL-4 and IL-13) is approved for inadequately controlled moderate-to-severe AD and for moderate-to-severe eosinophilic or oral corticosteroid-dependent asthma.ObjectiveThe aim was to determine the impact of dupilumab on infection rates in patients w...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
CONCLUSION: Adults and children with HS had increased acute and chronic, cutaneous, extra-cutaneous, and systemic infections, which were associated with increased mortality and cost. This article is protected by copyright. All rights reserved. PMID: 31049925 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Gulcin Tezcan1, Ekaterina V. Martynova1, Zarema E. Gilazieva1, Alan McIntyre2, Albert A. Rizvanov1 and Svetlana F. Khaiboullina1,3* 1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia 2Centre for Cancer Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom 3Department of Microbiology and Immunology, University of Nevada, Reno, Reno, NV, United States Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We report here a patient with a novel DSP spectrin region (SR) 6 variant c.1756C>T, p.(His586Tyr), novel features of brain lesions and severe recurrent mucocutaneous herpes simplex virus infections, with a favourable response to ustekinumab. Through a review of reported cases of heterozygous variants in DSP SR6 (n = 15) and homozygous or compound heterozygous variants in DSG1 (n = 12) and SAM-like phenotype, we highlight phenotypic variability. Woolly hair, nail abnormalities and cardiomyopathy characterize patients with DSP variants, while elevated immunoglobulin E and food allergies are fre...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
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