Dose-response association between vitamin D deficiency and atopic dermatitis in children, and effect modification by gender: A case-control study.

Dose-response association between vitamin D deficiency and atopic dermatitis in children, and effect modification by gender: A case-control study. J Dermatolog Treat. 2019 Jul 12;:1-25 Authors: Ahmed Mohamed A, Salah Ahmed EM, Farag YM, Bedair NI, Nassar NA, Ghanem AIM Abstract Background: Vitamin D is a regulatory factor for immunity and skin barrier functions. It is hypothesized to be linked to atopic dermatitis (AD) which is characterized by interaction between epidermal barrier dysfunction and dysregulation of skin immune functions. Methods: One hundred AD patients and one hundred and one normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of 25-hydroxyvitamin D [25(OH)D]. We assessed the relationship between 25(OH)D deficiency and AD prevalence using adjusted Poisson regression model. Results: Serum 25(OH)D levels were significantly lower in cases than controls (mean 35.1 vs 22.6 ng/mL, p 
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Background: Epidemiologic research has found links between vitamin D and atopic diseases. There is scarcity of prospective studies assessing the correlation between vitamin D deficiency and atopic dermatitis (AD).
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Authors: Stanley Xavier A, Selvarajan S, Chandrasekar L, Kamalanathan S Abstract Allergic contact dermatitis following exposure to Parthenium is a chronic disease associated with frequent relapses and significant disturbance in the quality of life. The affected patients have lower circulating levels and decreased expression of IL-10. Hence, measures to increase its level may enhance the therapeutic outcome. The clinical trial was undertaken to evaluate the effect of cholecalciferol supplementation on treatment response and IL-10 level in Parthenium dermatitis patients with vitamin D deficiency. A total of 72 patien...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.Dermatology
Source: Dermatology - Category: Dermatology Source Type: research
Conclusions: The prevalence of vitamin D deficiency/insufficiency was high in our sample. Vitamin D concentrations were directly associated with vitamin D supplementation until 2 years of age and were inversely associated with wheezing events in the first year of life, personal history of atopic dermatitis, and environmental pollution.RESUMO Objetivo: Determinar a preval ência da deficiência/insuficiência de vitamina D em indivíduos com sibilância recorrente e/ou asma com idade de 0-18 anos e residentes na microrregião de Viçosa (MG) atendidos em um centro de referência e ...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
Due to the hypomethylation and consequently increased expression of oxidative stress-promoting genes in severely vitamin D-deficient fetus, the resulting offspring is predisposed to subsequent AD development and its severity.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Publication date: March 2018Source: Hematology/Oncology and Stem Cell Therapy, Volume 11, Issue 1Author(s): João Tadeu Damian Souto Filho, Alícia Souza de Andrade, Felipe Mesquita Ribeiro, Paola de Araujo Sardenberg Alves, Virgínia Ribeiro Fernandes SimoniniAbstractObjective/backgroundVitamin D has been increasingly recognized as an immunomodulatory agent. Its deficiency has been associated with immune-mediated diseases such as asthma, rhinitis, and atopic dermatitis. These allergic conditions are dependent on T-helper type 2 (Th2) cells secreting interleukins, overproduction of immunoglobulin E (IgE),...
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
Abstract INTRODUCTION AND OBJECTIVES: Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. Apart from its well-known role on calcium metabolism, vitamin D is reported to affect skin functions. The study aims were to: compare the vitamin D levels of children with AD and healthy children; investigate the relationship between the severity of AD and vitamin D levels; and investigate the effect of vitamin D on the natural course of AD. PATIENTS OR MATERIALS AND METHODS: Sixty-nine patients with AD were enrolled. Seventy healthy children were assigned as control group. Clinical and demographic feat...
Source: Allergologia et Immunopathologia - Category: Allergy & Immunology Authors: Tags: Allergol Immunopathol (Madr) Source Type: research
Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.Skin Pharmacol Physiol 2018;31:74-86
Source: Skin Pharmacology and Physiology - Category: Dermatology Source Type: research
This study analyzes serum vitamin D in pediatric medical center patients with AD and potential confounding factors. At Cardinal Glennon Children's Hospital, charts of 665 children with serum 25-hydroxyvitamin D levels taken between 2009 and 2013 were retrospectively reviewed. Defining vitamin D deficiency as
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
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