Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x-ray, proton and carbon-ion beams.

Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x-ray, proton and carbon-ion beams. Phys Med Biol. 2019 Jul 11;: Authors: Rudek B, McNamara AL, Ramos-Mendez J, Byrne H, Kuncic Z, Schuemann J Abstract Gold nanoparticle (GNP) radio-enhancement is a promising technique to increase the dose deposition in a tumor while sparing neighboring healthy tissue. Previous experimental studies showed effects on cell survival and tumor control for keV x-rays but surprisingly also for MV-photons, proton and carbon-ion beams. In a systematic study, we use the Monte Carlo simulation tool TOPAS-nBio to model the GNP radio-enhancement within a cell as a function of GNP concentration, size and clustering for a wide range of energies for photons, protons and, for the first time, carbon-ions. Moreover, we include water radiolysis, which has been recognized as a major pathway of GNP mediated radio-enhancement. 
 At a GNP concentration of 0.5% and a GNP diameter of 10nm, the dose enhancement ratio was highest for 50keV x-rays (1.36) and decreased in the orthovoltage (1.04 at 250keV) and megavoltage range (1.01 at 1MeV). The dose enhancement linearly increased with GNP concentration and decreased with GNP size and degree of clustering for all radiation modalities. While the highest physical dose enhancement at 5% concentrations was only 1.003 for 10MeV protons and 1.004 for 100MeV carbon-ions, we find the number of hydroxyl OH altered by 23...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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Publication date: Available online 15 August 2019Source: Chemico-Biological InteractionsAuthor(s): Vernon E. Walker, Amanda Degner, Elizabeth W. Carter, Janice A. Nicklas, Dale M. Walker, Natalia Tretyakova, Richard J. AlbertiniAbstractEpidemiological studies of 1,3-butadiene (BD) exposures have reported a possible association with chronic myelogenous leukemia (CML), which is defined by the presence of the t(9;22) translocation (Philadelphia chromosome) creating an oncogenic BCR-ABL fusion gene. Butadiene diepoxide (DEB), the most mutagenic of three epoxides resulting from BD, forms DNA-DNA crosslink adducts that can lead ...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
This study reported a case of an 80-year-old man with a left total knee arthroplasty (TKA) performed eight years before his presentation. He presented with left knee swelling and pain for one month. Knee X-rays showed a normal joint space with no loosening of his prosthesis. His chest X-ray showed miliary disease, and microbiological studies of his sputum and synovial fluid aspirate grew Mycobacteria tuberculosis complex.
Source: The Knee - Category: Orthopaedics Authors: Tags: Case report Source Type: research
Conclusions: In this real-life cohort of patients with axSpA, although males more often had structural damage on X-rays, females had similar disease with regard to SpA features and at least equal disease activity parameters compared to males. PMID: 31418321 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
The idea to split soft X-ray and hard X-ray beams on the same axis into different directions is presented. A thin-film beam splitter can serve this purpose. Performances of thin-film beam splitters made of carbon and aluminium were examined. The idea of thin-film beam splitters expands possibilities in the design of two-colour beamlines.
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Tags: beam splitter soft and hard X-rays two-colour beamline research papers Source Type: research
CONCLUSIONS: Our proposed approach achieves significant performance improvements compared with the existing methods based on the original CNN or pure variational models. PMID: 31403960 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Conclusions: As a result, panoramic radiographs taken during dental diagnosis and treatment cause cytotoxicity and DNA damage in oral mucosal cells. Panoramic radiographs should be applied only when necessary, using an accurate radiographic technique and radioprotection criteria.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
ConclusionsThis is the first case description of association of multisegmental lumbar transverse process fractures with notoriously unstable injuries of the major soft-tissue stabilizers of the spine presenting subtle changes on CT images. When a seemingly benign spinal injury is caused by high-energy trauma, careful scrutiny for associated instability is needed. In this case, the standing in-brace X-ray was able to avoid a misdiagnosis and potentially unfavourable outcome.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
Publication date: October 2019Source: Thermochimica Acta, Volume 680Author(s): Agnieszka Kiełboń, Anna Michnik, Kinga Polaczek Grelik, Klaudia Duch, Ewa Sadowska-KrępaAbstractDifferential scanning calorimetry (DSC) has been employed to examine the thermal behavior of blood serum solutions affected by X-rays. The aim of this paper was to investigate the effect of 10 Gy dose on sera DSC profiles on the first day after exposure and to monitor changes over time. The clearest symptoms of aging of serum solutions during 2 weeks were the shift of the endothermic protein denaturation toward higher temperatures and the ap...
Source: Thermochimica Acta - Category: Chemistry Source Type: research
The authors aimed to define the incidence of unilateral pulmonary edema (UPE) within the first 24 hours after minimally invasive cardiac surgery without one lung ventilation techniques based on assessment of chest x-rays.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
This article originally appeared on Medium here.
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Technology Medical Practice Physicians AI Alex Logsdon Artificial intelligence Radiology Source Type: blogs
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