A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studi...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research

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Condition:   Plasmodium Falciparum Malaria Interventions:   Diagnostic Test: Ultrasensitive Rapid Diagnostic Test (URDT);   Drug: Antimalarials Sponsor:   University of Oxford Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Scientists in Burkina Faso have deployed a new weapon in the fight against malaria, and waded into a thorny bioethics debate, by letting loose thousands of genetically sterilized mosquitoes.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
[Radio Dabanga] El Fasher / Nyala / Blue Nile -At least eight people have died of malaria in North Darfur this week, while doctors at El Fasher Teaching Hospital recorded at least 1,000 malaria cases.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[The Conversation Africa] Many people in Africa are food insecure, vulnerable to shifts in climate and do not have access to electricity. There's also a problem with accessing reliable, clean water, particularly in places with irregular rains.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
In conclusion, TQ was cost-effective in comparison to PQ for radical cure of PV malaria in socio-economic settings of a South-Eastern European country. PMID: 31524099 [PubMed - as supplied by publisher]
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
The participation of cytokines and chemokines in Plasmodium vivax malaria (Pv-malaria) activates the immune response and thus causes the production of several inflammatory mediators. This process is already well-established, but little is known about eicosanoids in malaria physiopathology, especially in regards to inflammation and immunity. Malaria is an acute febrile syndrome similar to any other less important infectious disease and people may self-medicate with any anti-inflammatory drugs in order to cease the recurrent symptoms of the disease. Based on this information, the study describes the eicosanoid profile and it...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Vaccination is an effective strategy to control influenza disease. Adjuvants enhance the efficacy of vaccines, but few adjuvants are approved for human use, so novel, safe, and effective adjuvants are urgently needed. The glycolipid adjuvant 7DW8-5 has shown adjuvanticity to malaria vaccine; however, its adjuvant effect for seasonal influenza vaccine remains unknown. Here, we evaluated the adjuvanticity of 7DW8-5 to a quadrivalent split influenza vaccine in a mouse model. 7DW8-5 significantly enhanced virus-specific antibody production when administrated with influenza vaccine compared with that of vaccine alone; 10 μg ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Dhiman The future implications of climate change on malaria transmission at the global level have already been reported, however such evidences are scarce and limited in India. Here our study aims to assess, identify and map the potential effects of climate change on Plasmodium vivax (Pv) and Plasmodium falciparum (Pf) malaria transmission in India. A Fuzzy-based Climate Suitability Malaria Transmission (FCSMT) model under the GIS environment was generated using Temperature and Relative Humidity data, extracted from CORDEX South Asia for Baseline (1976–2005) and RCP 4.5 scenario for future projection by the ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Camarlinghi G, Parisio EM, Nardone M, Mancini F, Ciervo A, Boccolini D, Mattei R Abstract Both malaria and relapsing fever Borrelia are infectious diseases characterized by fever, headache, myalgia, hepatosplenomegaly and tendency to relapse. Exflagellation of microgametocyte in malarial parasites is seen only in the definitive host, i.e., mosquitoes. Here we report an unusual case of a 23-year-old man who presented Plasmodium vivax infection with multiple exflagellated microgametes in the peripheral blood smear. PMID: 31524945 [PubMed - as supplied by publisher]
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
[New Dawn] Former President Ellen Johnson Sirleaf travelled on Thursday, September 12, 2019 to participate in meetings in the margins of the United Nations relating to her role as a WHO Goodwill Ambassador and member of Bill Gates and Malaria Council.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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