Innovative therapies for neovascular age-related macular degeneration.

Innovative therapies for neovascular age-related macular degeneration. Expert Opin Pharmacother. 2019 Jul 12;:1-13 Authors: Al-Khersan H, Hussain RM, Ciulla TA, Dugel PU Abstract Introduction: Investigational anti-VEGF treatments for neovascular age-related macular degeneration (nAMD) aim to improve visual outcomes and reduce treatment burden; these include long-acting agents, combination strategies, topical agents, sustained-release, and genetic therapies. Areas covered: The authors provide a comprehensive review of investigational therapies for nAMD, focusing on therapies currently in clinical trial. Expert opinion: Long-acting anti-VEGF agents have demonstrated promising results in phase 3 studies, and include Brolucizumab, a single-chain antibody fragment, and Abicipar, a designed ankyrin repeat protein (DARPin). Other unique anti-VEGF agents in current trials include Conbercept - a fusion protein of the VEGF receptor domains, KSI-301 - an anti-VEGF antibody biopolymer conjugate, and OPT-302 - an inhibitor of VEGF-C/D. Strategies to activate the Tie-2 receptor, some in combination with VEGF inhibition, are of interest, with recent trials of Faricimab, ARP-1536, and nesvacumab. Topical anti-VEGF ± anti-PDGF agents, such as pazopanib, squalamine lactate, regorafenib, and LHA510 have shown limited efficacy and/or have not been advanced, although PAN-90806 continues to advance with promising initial results. Sustained-release anti-VEGF treatme...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

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WEDNESDAY, Aug. 21, 2019 -- Chronic exposure to high levels of nitrogen dioxide (NO2) and carbon monoxide (CO) is associated with an increased risk for age-related macular degeneration (AMD) in a population in Taiwan, according to a study published...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(Reuters Health) - Exposure to high levels of exhaust may raise the risk of the vision robbing disease called age-related macular degeneration (AMD), a new study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
CONCLUSION: The reliability (intra-session repeatability and inter-examiner reproducibility) of colour perimetry technique to assess macular pigment optical density in age-related macular degeneration patients is only moderate. Thus, it cannot be recommended to be performed when evaluating and monitoring age-related macular degeneration patients in the daily clinic. PMID: 31422700 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
Abstract Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone system (RAAS) and have a central role in hypertension as well as cardiovascular and renal disease. The localization of RAAS components within the retina has led to studies investigating the roles of angiotensin II, aldosterone and the counter regulatory arm of the pathway in vision-threatening retinopathies. This review will provide a brief overview of RAAS components as well as the vascular pathology that develops in the retinal diseases, retinopathy of prematurity, diabetic retinopathy and neovascular age-related ...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Jutta Schröder-Braunstein, Michael KirschfinkAbstractComplement defects are associated with an enhanced risk of a broad spectrum of infectious as well as systemic or local inflammatory and thrombotic disorders. Inherited complement deficiencies have been described for virtually all complement components but can be mimicked by autoantibodies, interfering with the activity of specific complement components, convertases or regulators. While being rare, diseases related to complement deficiencies are often severe with a frequent but not exclu...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Condition:   Neovascular Age-related Macular Degeneration Interventions:   Biological: Eylea;   Biological: ALT-L9 Sponsor:   Alteogen, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Obesity and the metabolic syndrome II Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutritional epidemiology II Source Type: research
Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clini...
Source: Immunity and Aging - Category: Geriatrics Authors: Tags: Research Source Type: research
Although visual acuity and optical coherence tomography (OCT) are most widely used as outcomes in treatment of neovascular age-related Macular Degeneration (nAMD), patient reported outcome measures are increas...
Source: Health and Quality of Life Outcomes - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research
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