The missing link: allostery and catalysis in the anti-viral protein SAMHD1.
We present a comprehensive mechanism detailing the structural and protein dynamics components of the allosteric coupling between nucleotide-induced tetramerization and the catalysis of dNTP hydrolysis by SAMHD1.
PMID: 31296733 [PubMed - as supplied by publisher]
Source: Biochemical Society Transactions - Category: Biochemistry Authors: Morris ER, Taylor IA Tags: Biochem Soc Trans Source Type: research
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