RP5-1120P11.3 promotes hepatocellular carcinoma development via hsa-miR-196b-5p/WIPF2 axis.

RP5-1120P11.3 promotes hepatocellular carcinoma development via hsa-miR-196b-5p/WIPF2 axis. Biochem Cell Biol. 2019 Jul 12;: Authors: Zhai H, Zhang X, Chen S, Fan M, Ma S, Sun X Abstract Hepatocellular carcinoma (HCC) remains a huge threat to human health although the diagnosis and treatment strategies have been improved rapidly in the past few decades. Increasing evidence has illustrated the roles of non-coding RNA and their regulatory network which plays critical roles in pathology of HCC. Here, we identified a novel long non-coding RNA, RP5-1120P11.3 that ectopically expressed in HCC. Further characterization of RP5-1120P11.3 revealed that RP5-1120P11.3 promoted proliferation and invasion of HCC while inhibited apoptosis. Importantly, our data revealed that miR-196b-5p interacted with and was regulated by RP5-1120P11.3 via a sponging mechanism. Inhibition of miR-196b-5p attenuated the phenotypes resulted from RP5-1120P11.3 inhibition. Moreover, our data showed that miR-196b-5p inhibited the expression of WIPF2 in HCC and thus illustrated a regulatory axis of RP5-1120P11.3/miR-196b-5p/WIPF2 that facilitated the progression of HCC. In addition, our data showed that RP5-1120P11.3 contributed to the xenograft generation in vivo via regulating miR-196b-5p and WIPF2. These findings suggested that RP5-1120P11.3/miR-196b-5p/WIPF2 axis is a potential target for treatment of HCC. PMID: 31299165 [PubMed - as supplied by publisher]
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Biochem Cell Biol Source Type: research