Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides.
Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides.
Chem Commun (Camb). 2019 Jul 12;:
Authors: Okamoto H, Taniguchi A, Usami S, Taguchi A, Takayama K, Hayashi Y
Abstract
Inhibition of myostatin is an attractive treatment for muscular dystrophy and other amyotrophic diseases. A myostatin-binding peptide was functionalized by equipped with an on/off switchable photo-oxygenation catalyst. This peptide induces a selective oxygenation of myostatin under near-infrared light, resulting in inactivation of myostatin. This peptide shows several orders of magnitude greater inhibitory effect than the original peptide.
PMID: 31298230 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Okamoto H, Taniguchi A, Usami S, Taguchi A, Takayama K, Hayashi Y Tags: Chem Commun (Camb) Source Type: research