Multiple Regulatory Variants Modulate Expression of 5-Hydroxytryptamine 2A Receptors in Human Cortex

Conclusions: Regulatory polymorphisms modulate HTR2A mRNA expression in an isoform-specific manner, directing the usage of novel untranslated regions and alternative exons. These results provide a foundation for delineating the role of HTR2A and serotonin signaling in central nervous system disorders.

Source: Biological Psychiatry - November 15, 2012 Category: Psychiatry Authors: Ryan M. Smith, Audrey C. Papp, Amy Webb, Cara L. Ruble, Leanne M. Munsie, Laura K. Nisenbaum, Joel E. Kleinman, Barbara K. Lipska, Wolfgang Sadee Tags: Archival Reports Source Type: research