Measles

Review and case vignette covered measles in the US and globally, clinical presentation, diagnosis, management, postexposure prophylaxis, vaccine effectiveness/ safety, general recommendations for measles vaccination, areas of uncertainty, and guidelines.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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We describe the clinical presentation and outcome of hospitalized patients during the outbreak.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0633 Source Type: research
r U Abstract Measles outbreaks occur rather frequently in Germany. Patients with chronic inflammatory diseases are often treated with immunosuppressants. A recent study showed that about 7% of such patients are not protected against measles according to the lack of documentation in the vaccination card or the absence of protective antibodies. The Standing Committee on Immunization (STIKO) recommends a first vaccination against measles as a measles-mumps-rubella combined vaccination (MMR) in children aged 11-14 months and a second vaccination at 14-23 months. For adults born after 1970, vaccination against measles ...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
History illustrates the remarkable public health impact of mass vaccination, by dramatically improving life expectancy and reducing the burden of infectious diseases and co-morbidities worldwide. It has been perceived that if an individual adhered to the MMR vaccine schedule that immunity to mumps virus (MuV) would be lifelong. Recent mumps outbreaks in individuals who had received two doses of the Measles Mumps Rubella (MMR) vaccine has challenged the efficacy of the MMR vaccine. However, clinical symptoms, complications, viral shedding and transmission associated with mumps infection has been shown to be reduced in vacci...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Background: In 2000, endemic measles was declared eliminated in the US. However, a proliferation of anti-vaccination sentiment over the last decade has led to measles ’ re-emergence, with 2019 experiencing the most measles cases in the US since 1992. Rising rates of non-medical exemptions (NMEs) and low vaccination coverage in the state of Michigan prompted an administrative vaccine policy change in 2015, mandating that parents attend an in-person vaccine educa tion session prior to obtaining a non-medical exemption waiver.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0565 Source Type: research
Background: Despite the availability of safe and effective vaccines, measles resurgence has been observed worldwide in 2018 and 2019. In West Indian Ocean (WIO), almost all islands have reported measles cases during these years. Vaccine coverage was particularly low in Madagascar and Comoros Island, with a single dose provided by the Expanded Program on Immunization.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0526 Source Type: research
We describe a 2 year old boy with two previously undescribed frameshift mutations in the interferon (IFN)α/β receptor 2 (IFNAR2) gene presenting with hemophagocytic lymphohistiocytosis (HLH) following measles-mumps-rubella vaccination. Functional analyses show the absence of response to type I IFN in the patient’s cells, as revealed by the lack of phosphorylation of STAT1 and the lack of induction of interferon-stimulated genes upon ex vivo stimulation with IFNα. HLH has been reported in patients with inborn errors of type I IFN-mediated immune responses following vaccination with live-attenuated vir...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
(American Chemical Society) Vaccines have curtailed the spread of several infectious diseases, such as smallpox, polio and measles. However, vaccines against some diseases, including HIV-1, influenza and malaria, don't work very well, and one reason could be the timing of antigen and adjuvant presentation to the immune system. Now, researchers reporting inACS Central Science developed an injectable hydrogel that allows sustained release of vaccine components, increasing the potency, quality and duration of immune responses in mice.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
While the world waits for a COVID-19 vaccine, children across the globe are going without shots already known to be life-saving. With the world in disarray due to the COVID-19 pandemic, the number of children vaccinated this year against infections like diphtheria, tetanus, pertussis, measles and pneumococcal disease has fallen to levels not seen since the 1990s, according to a new report from the Bill and Melinda Gates Foundation. “In other words,” the report reads, “we’ve been set back about 25 years in about 25 weeks.” That stark figure comes from the Gates Foundation’s annual Goalkee...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
CONCLUSION: These data show that at least 2.9% of the patients did not have sufficient protection against measles. Interestingly, the majority of patients born after 1970 had protective antibodies despite the lack of vaccination against measles. The efforts in primary and also in the specialist medical care should be urgently strengthened in order to be able to guarantee an adequate infection prophylaxis in particularly endangered patients. PMID: 32930874 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
Nonurgent medical procedures have seemed worth postponing in a pandemic. This could pose long-term risks, health officials fear.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Preventive Medicine Coronavirus (2019-nCoV) Vaccination and Immunization Medicine and Health Quarantines Measles Source Type: news
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