Preliminary assessment of anti- α-Gal IgG and IgM levels in patients with patent Plasmodium vivax infection.

Preliminary assessment of anti-α-Gal IgG and IgM levels in patients with patent Plasmodium vivax infection. Mem Inst Oswaldo Cruz. 2019;114:e190145 Authors: Coelho ZBA, Mourão LC, Rodrigues BCM, Cardoso-Oliveira GP, Hincapie R, Sanhueza-Chavez C, Finn MG, Fontes CJF, Marques AF, Braga ÉM Abstract Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria. PMID: 31291383 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research