Breathing: Ambient Air Pollution and Health - Part III.
[Breathing: Ambient Air Pollution and Health - Part III]. Pneumologie. 2019 Jul;73(7):407-429 Authors: Schulz H, Karrasch S, Bölke G, Cyrys J, Hornberg C, Pickford R, Schneider A, Witt C, Hoffmann B Abstract The third part of the DGP statement introduces the current body of knowledge on less studied health outcomes associated with exposure to ambient air pollution: the negative impact on metabolism leading to impaired glucose tolerance and diabetes as well as contribution to the development of neurodegenerative disorders and delayed cognitive function in children. Furthermore, prenatal exposure and adverse effects on mother and child are addressed. Finally, the currently discussed biological mechanisms underlying various health effects associated with exposure to air pollution are described.Differing, but often complementary biological mechanisms create the basis for the diverse health outcomes caused by air pollution. Oxidative stress and a subclinical inflammatory response in the lungs and on a systemic level ("low-grade systemic inflammation") are considered to be key mechanisms. They promote secondary alterations in the body, such as vascular or metabolic processes, and may also result in the currently studied epigenetic phenomena or neuroinflammation. In this context, the health significance of soluble particulate matter and the role of ultrafine particles translocated across biological membranes into blood vessel and transported via t...
Authors: Wan Ab Rahman WS, Abdullah WZ, Husin A, Nik Mohd Hassan NFF, Hassan MN, Zulkafli Z Abstract INTRODUCTION: Acquired haemophilia A (AHA) is a rare acquired bleeding disorder caused by polyclonal immunoglobulin G autoantibodies against clotting factor VIII (FVIII). The incidence was reported to be rare occurring in 0.2- 4 cases/million/year. Patients may present with different clinical manifestations to various specialties. Early recognition of the disease contributes to favourable clinical outcome. CASE SERIES: Here, we reported five cases of this disorder with different clinical presentations from two t...
Little information is available about the risk of end-stage renal disease (ESRD) after preeclampsia. The review of Covella et al. demonstrated that former preeclamptic women have a significant risk of ESRD in the medium term. However, it is still unknown which preeclamptic woman are at higher risk for progressive kidney disease. After delivery, women who had preeclampsia, particularly those with persistent hypertension, symptomatic proteinuria, or microalbuminuria, should receive a regular checkup for kidney disease.
Although control of chronic glycemia in the population with diabetes and end-stage renal disease (ESRD) has been extensively studied in recent years, the unique problems of short-term glycemic management in acutely ill patients undergoing dialysis have received little attention. Bally et al. evaluated the role of a “closed-loop” (glucose sensor/algorithm tablet device/insulin pump) system in a cohort of hospitalized patients with type 2 diabetes receiving hemodialysis. Compared with usual care, the intervention group had superior glycemic control without increased hypoglycemic events.
An 82-year-old male, with a history of bowel cancer with partial colectomy, gastroesophageal reflux disease, remote partial gastrectomy for peptic ulcer disease, and no documented prior kidney disease, presents with several months of fatigue and subacute decline in kidney function. He had no history of diabetes, hypertension, kidney stones, or prior urinary tract infections. He denied use of nonsteroidal anti-inflammatory agents, herbal medications, and recent antibiotics. There was no family history of renal disease.
Authors: Carretero-Anibarro E, Hamud-Uedha M PMID: 31427152 [PubMed - as supplied by publisher]
CONCLUSIONS: Dapagliflozin, in subjects with DM2, produces a medium to long-term decrease in arterial stiffness. PMID: 31420083 [PubMed - as supplied by publisher]
CONCLUSIONS: There were no significant differences in the clinical and obstetric variables analysed between pregnant women exposed to DMDs, unexposed, and HPW. PMID: 31420082 [PubMed - as supplied by publisher]
We report a case of splenic trauma during the third trimester of pregnancy that was successfully treated by arterial embolization with preservation of the spleen. This rarely reported management strategy during pregnancy had a favorable outcome. Such a strategy should be discussed and considered, taking into account maternal, obstetrical and fetal factors.
The Wound Ischemia foot Infection (WIfI) classification has gained widespread acceptance in the vascular community as a method of categorizing disease severity in patients with chronic limb-threatening ischemia (CLTI). The original WIfI system is based on a Delphi consensus model, which relies on an iterative process of consensus amongst experts, but is not necessarily data driven. Twelve experts were selected in the formation of the initial WIfI model. The WIfI classification was initially developed in a cohort of CLTI patients not undergoing revascularization, but since then has been extrapolated to predict outcomes of m...
This study aimed to assess the impact of perioperative hemoglobin A1c (HbA1c) levels on short- and long-term results after LEB.
More News: Allergy | Allergy & Immunology | Alzheimer's | Brain | Child Development | Children | Dementia | Diabetes | Diabetes Type 2 | Endocrinology | Environmental Health | Epidemiology | Germany Health | Hypertension | Insulin | Liver | Neurology | Pregnancy | Respiratory Medicine | Study | Urology & Nephrology