Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections.

Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections. Eur J Pharm Biopharm. 2019 Jul 08;: Authors: Censi R, Casadidio C, Dubbini A, Cortese M, Scuri S, Grappasonni I, Golob S, Vojnovic D, Giovanna Sabbieti M, Agas D, Di Martino P Abstract The purpose of this work was the development of antibacterial delivery systems for vancomycin, with potential application in the prevention of orthopedic implant infections. Previous studies have shown tandem thermal gelling and Michael addition cross-linking of hydrogels based on (meth)acrylated triblock copolymers of PEG-p(HPMAm-lac1-2) and thiolated hyalutronic acid. In this work we extended this technology synthesizing new vinyl sulfone derivatives of PEG-p(HPMAm-lac1-2) triblock copolymers and used them in combination with thiolated hyaluronic acid as controlled delivery systems for vancomycin. It was found that the antibiotic was sustainably released from the hydrogel networks for at least 5 days with release kinetics depending on diffusion and dissociation of the positively charged vancomycin from the negatively charged hyaluronic acid. The release of vancomycin could be tailored mainly by HA-SH solid content and degree of thiolation. The developed hydrogels were demonstrate efficacious in preserving the structural and functional integrity of the encapsulated drug by physical immobilization within the gel networ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Biopharm Source Type: research