New Insights into Mechanisms of Acute Kidney Injury in Heart Disease

Publication date: Available online 11 July 2019Source: Canadian Journal of CardiologyAuthor(s): Sriram Sriperumbuduri, Edward Clark, Swapnil HiremathAbstractAcute kidney injury is frequent occurrence in patients with heart disease, and is associated with higher risk of adverse outcomes, including mortality. In the setting of decompensated heart failure, acute kidney injury can occur from haemodynamic and neurohormonal activation, venous congestion, and nephrotoxic medications. Certain medications, such as loop diuretics, renin angiotensin system blockers, and mineralocorticoid antagonists can seemingly cause acute kidney injury. However this rise in creatinine is not always associated with adverse outcomes and should be carefully differentiated so as to allow deliberate continuation of these cardio- and nephro-protective agents. In other settings such as cardiac surgery, acute kidney injury can occur from factors related to the cardiopulmonary bypass, renal hypoperfusion or other perioperative factors. Lastly patients with heart disease commonly undergo imaging procedures which require contrast administration. Contrast can indeed cause acute kidney injury, but these interventional procedures also can result in kidney injury from atheroembolic phenomena. This is well demonstrated by the recent data reporting a higher risk of acute kidney injury from femoral compared to radial access. The advent of biomarkers of kidney injury it presents an opportunity for early detection, accu...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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Publication date: Available online 21 August 2019Source: Journal of Science and Medicine in SportAuthor(s): Tom E. Nightingale, Gurjeet S. Bhangu, James L.J. Bilzon, Andrei V. KrassioukovAbstractObjectivesTo assess; (1) differences in red blood cell distribution width between individuals with chronic (>1 year), motor-complete cervical (n = 21), upper-thoracic (n = 27) and thoracolumbar (n = 15) spinal cord injury and, (2) associations between red blood cell distribution width and cardiorespiratory fitness.DesignProspective multi-center, cross-sectional study.MethodsPeak o...
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Publication date: Available online 21 August 2019Source: Journal of Geriatric OncologyAuthor(s): Guillaume Beinse, Delphine Reitter, Lauriane Segaux, Muriel Carvahlo-Verlinde, Benoit Rousseau, Christophe Tournigand, Tristan Cudennec, Marie Laurent, Pascaline Boudou-Rouquette, Elena Paillaud, Florence Canouï-Poitrine, Philippe Caillet, for the ELCAPA Study GroupAbstractBackgroundBecause of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with ca...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
High molecular weight kininogen (HK) and prekallikrein (PK) are proteins in the kallikrein/kinin system of the coagulation cascade. They play an important role in the contact activation system of the intrinsic coagulation pathway, renin-angiotensin activation, and inflammation. Hence these proteins have been posited to affect the occurrence of cardiovascular events and thus to be potential therapeutic targets. Previous case-control studies have provided inconsistent evidence for an association of HK and PK with cardiovascular disease.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research
Insomnia may raise the risk of cardiovascular disease, heart failure and stroke. For the study, the researchers looked at data from multiple studies for 1.3 million people with and without heart disease and stroke.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
CONCLUSIONS: A transition from the anesthesia to the ICU service for transporting ICU patients to the OR did not change turnover times but resulted in more on-time starts and high compliance with preoperative checklist documentation. PMID: 31425206 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
In this study, we used large-scale electronic health records data from multiple linked UK databases to address these evidence gaps.MethodsFor this population-based cohort study, we used linked primary care, hospital, and cancer registry data from the UK Clinical Practice Research Datalink to identify cohorts of survivors of the 20 most common cancers who were 18 years or older and alive 12 months after diagnosis and controls without history of cancer, matched for age, sex, and general practice. We compared risks for a range of cardiovascular disease outcomes using crude and adjusted Cox models. We fitted interactions to in...
Source: The Lancet - Category: General Medicine Source Type: research
AbstractBackgroundFunctional limitations may be more common in middle-aged adults than previously recognized. However, there are few published data on the prevalence of activity limitations, and their association with multimorbidity, among adults 50 to 64  years old.ObjectiveTo describe the prevalence of activity limitations and the association with multimorbidity in middle-aged adults.DesignCross-sectional analysis of US population-based National Health and Nutrition Examination Survey (NHANES) 2011 –2016.ParticipantsThe total number of community-dwelling NHANES participants aged 50 –64 years old is ...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Conclusion: Right ventricular systolic function is impaired in patients with heart failure secondary to hypertensive heart disease.  There is no relationship between the indices of right ventricular systolic function and systolic pulmonary artery pressure. Furtherstudies are needed to assess right ventricular systolic function in Nigerians.Keywords: Hypertension, Heart Failure, Right ventricular dysfunction, Nigeria, Sub- Saharan Africa.
Source: African Health Sciences - Category: African Health Source Type: research
Experts have long thought that an ex-smoker's risk of heart attack, stroke, heart failure or death from heart disease returns to normal within five years.
Source: WebMD Health - Category: Consumer Health News Source Type: news
AbstractThere are few data on the effects of low hemoglobine levels on the left atrium (LA) in anemic patients. Our aim was to evaluate left atrial (LA) volume and functions in anemic patients using real time three-dimensional echocardiography (RT3DE) and also to investigate changes in variables of LA after the correction of anemia. In total, 55 iron-deficiency anemia patients without traditional cardiovascular (CV) risk factors and 30 age- and gender-matched controls were studied. Assessments included history, physical examination and echocardiography. Of the 55 patients with anemia enrolled, 50 (39 females and 11 males 4...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
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