Association between temporal changes in C-reactive protein levels and prognosis in patients with previous myocardial infarction - A report from the CHART-2 Study

Several studies have reported that C-reactive protein (CRP), an inflammatory biomarker, predicts cardiovascular events independently of low-density lipoprotein cholesterol levels. However, no study examined whether temporal changes in CRP levels are associated with clinical events in patients with previous myocardial infarction (MI).
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research

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Publication date: Available online 19 August 2019Source: Canadian Journal of DiabetesAuthor(s): Lucas C. Godoy, Caio A.M. Tavares, Michael E. FarkouhAbstractPatients with diabetes (DM) are at increased risk for developing coronary artery disease (CAD). Choosing the optimal revascularization strategy, i.e. coronary artery bypass grafting – CABG – or percutaneous coronary intervention – PCI, may be difficult in this population. A large body of evidence suggests that, for patients with DM and stable multivessel ischemic heart disease, CABG is usually superior to PCI, leading to lower rates of all-cause morta...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
A lack of sleep could lead to heart disease, weight gain – and even change the way our DNA behaves. Leading sleep expert Paul Gringras has revealed what happens to our bodies after a poor night's sleep, with higher blood pressure and cholesterol also among the potential consequences of not getting enough rest.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study aimed to investigate factors associated with orthostatic hypotension in 14,833 individuals 35-74 years of age. This was a cross-sectional study of baseline data (2008-2010) from the Longitudinal Study of Adult Health (ELSA-Brasil). Postural testing was performed after 20 minutes resting in supine position and active adoption of orthostatic posture. Blood pressure was measured in supine position and at 3 minutes in orthostatic position with an oscillometer (HEM 705 CP, Omron, São Paulo, Brazil). Orthostatic hypotension was defined as a drop of ≥ 20mmHg in systolic blood pressure and/or a drop of ≥ 10...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72Ô...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 9 August 2019Source: American Heart JournalAuthor(s): Kausik K. Ray, Stephen J. Nicholls, Henry Ginsberg, Jan O. Johansson, Kamyar Kalantar-Zadeh, Ewelina Kulikowski, Peter P. Toth, Norman Wong, Jeffrey L. Cummings, Michael Sweeney, Gregory G. SchwartzAbstractBackgroundAfter an acute coronary syndrome (ACS), patients with diabetes remain at high risk for additional cardiovascular events despite use of current therapies. Bromodomain and extra-terminal (BET) proteins are epigenetic modulators of inflammation, thrombogenesis, and lipoprotein metabolism implicated in atherothrombosis. The BET...
Source: American Heart Journal - Category: Cardiology Source Type: research
Purpose of review The use of therapeutic monoclonal antibodies to target proprotein convertase subtilisin/kexin type 9 (PCSK9) represents a novel approach to the management of hypercholesteremia and prevention of atherosclerotic cardiovascular disease. We review the most recent literature relevant to PCSK9 inhibition with emphasis on how recent results and ongoing trials have and will continue to shape the use of this new therapeutic class in preventive cardiology. Recent findings PCSK9 inhibitors reduce plasma lipoprotein(a) concentrations but a mechanistic understanding remains elusive. Evaluation of evolocumab for ...
Source: Current Opinion in Cardiology - Category: Cardiology Tags: PREVENTION: Edited by Ron Blankstein Source Type: research
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72Ô...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Older men and women who stopped taking the drugs were at increased risk of heart attack and stroke.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Heart Statins (Cholesterol-Lowering Drugs) Age, Chronological Source Type: news
Background and Aims: Patients with familial hypercholesterolemia (FH) have increased levels of LDL-cholesterol (LDL-C) and increased risk of premature cardiovascular disease (CVD) and early death. The aim of the present study was to investigate the prevalence of FH among young patients
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Posters 26 - 29 May, 2019 Source Type: research
Background and Aims: Lipid lowering therapies are the mainstay of secondary prevention after myocardial infarction (MI). However, non-adherence to statins is a major problem that leads to off-target LDL-C levels and higher rates of adverse cardiovascular events.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Posters 26 - 29 May, 2019 Source Type: research
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