Cancers, Vol. 11, Pages 976: Locally Advanced Pancreatic Cancer: Work-Up, Staging, and Local Intervention Strategies

Cancers, Vol. 11, Pages 976: Locally Advanced Pancreatic Cancer: Work-Up, Staging, and Local Intervention Strategies Cancers doi: 10.3390/cancers11070976 Authors: Eran van Veldhuisen Claudia van den Oord Lilly J. Brada Marieke S. Walma Jantien A. Vogel Johanna W. Wilmink Marco del Chiaro Krijn P. van Lienden Martijn R. Meijerink Geertjan van Tienhoven Thilo Hackert Christopher L. Wolfgang Hjalmar van Santvoort Bas Groot Koerkamp Olivier R. Busch I. Quintus Molenaar Casper H. van Eijck Marc G. Besselink the Dutch Pancreatic Cancer Group and International Collaborative Group on Locally Advanced Pancreatic Cancer Locally advanced pancreatic cancer (LAPC) has several definitions but essentially is a nonmetastasized pancreatic cancer, in which upfront resection is considered not beneficial due to extensive vascular involvement and consequent high chance of a nonradical resection. The introduction of FOLFIRINOX chemotherapy and gemcitabine-nab-paclitaxel (gem-nab) has had major implications for the management and outcome of patients with LAPC. After 4–6 months induction chemotherapy, the majority of patients have stable disease or even tumor-regression. Of these, 12 to 35% are successfully downstaged to resectable disease. Several studies have reported a 30–35 months overall survival after resection; although it currently remains unclear if this is a result of the resection or the good response to chemotherapy...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research