SGLT-2 (Sodium-Glucose Cotransporter 2) Inhibition Reduces Ang II (Angiotensin II)-Induced Dissecting Abdominal Aortic Aneurysm in ApoE (Apolipoprotein E) Knockout Mice.

CONCLUSIONS: Pharmacological inhibition of SGLT-2 by empagliflozin inhibits AAA formation. SGLT-2 inhibition might represent a novel promising therapeutic strategy to prevent AAA progression ( Visual Overview ). PMID: 31294626 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31294626?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 10, 2019 Category: Cardiology Authors: Ortega R, Collado A, Selles F, Gonzalez-Navarro H, Sanz MJ, Real JT, Piqueras L Tags: Arterioscler Thromb Vasc Biol Source Type: research