The association between interleukin ‐1 polymorphisms and their protein expression in Chinese Han patients with breast cancer

The association between genetic polymorphisms of IL ‐1 and breast cancer (BC) susceptibility in the Chinese Han population and indicates that IL‐1 polymorphisms are closely associated with tumor markers and IL‐1 βprotein expression in BC patients. AbstractBackgroundBreast cancer (BC) is the most common cancer in women and the second leading cause of cancer ‐related deaths among women worldwide. Single nucleotide polymorphisms (SNPs) in cytokine genes have been shown to alter their expressions or functions in patients with BC. In recent years, the molecular structure and function of IL‐1 have been studied. Its genetic polymorphism could affect the transcription and expression of the IL‐1 gene. Moreover, it is closely related to several diseases. This fact and plethora of gene polymorphism data prompted us to investigate the relationship between IL‐1 polymorphisms and IL‐1 protein expression in Chinese Han BC patients.MethodIn total, 298 patients with BC and 287 healthy control women were studied. The genetic polymorphisms for IL ‐1 were analyzed by the MassARRAY sequencing method. Tumor markers and IL‐1β levels were measured by electrochemiluminescence and ELISA, respectively. All gene selection GRCh38 version.ResultsThe rs1143623 (NC_000002.12:g.112838252C>G) (GC), rs16944 (NC_000002.12:g.112837290A>G)(AG), and rs10490571 (NC_000002.12:g.102100877C>T) (CC) SNPs were found to be significantly lower in the BC group than in the controls. Th...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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