Prejudice and Discrimination, the Uncured Ills of Leprosy

Nippon Foundation President Yohei Sasakawa and Socorro Gross, Pan American Health Organisation representative in Brazil, hold a press conference in Brasilia at the end of a 10-day visit to this country by the Japanese activist who is also World Health Organisation Goodwill Ambassador for Leprosy Elimination. Credit: Mario Osava/IPSBy Mario OsavaBRASILIA, Jul 11 2019 (IPS) “The ambulance team refused to take my sick friend to the hospital because he had had Hanseniasis years before,” said Yohei Sasakawa, president of the Nippon Foundation, at one of the meetings held during his Jul. 1-10 visit to Brazil. His friend was completely cured and had no visible effects of the disease, but in a small town everyone knows everything about their neighbours, he said. This didn’t happen in a poor country, but in the U.S. state of Texas, only about 20 years ago, Sasakawa pointed out to underline the damage caused by the discrimination suffered by people affected by Hansen’s Disease, better known as leprosy, as well as those who have already been cured, and their families. “The disease is curable, its social damage is not,” he said during a meeting with lawmaker Helder Salomão, chair of the Human Rights Commission in Brazil’s lower house of Congress, to ask for support in the fight against Hanseniasis, the official medical name for the disease in Brazil, where the use of the term leprosy has been banned because of the stereotypes and stigma su...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Civil Society Democracy Development & Aid Editors' Choice Headlines Health Human Rights Latin America & the Caribbean Population Regional Categories Brazil Hansen's disease leprosy Nippon Foundation Source Type: news

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Authors: Santos VS, de Souza CDF, Martins-Filho PRS, Cuevas LE PMID: 32250199 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
AbstractBuruli ulcer, the third most common mycobacterial disease worldwide, is caused byMycobacterium ulcerans and characterized by devastating necrotizing skin lesions. Susceptibility to Buruli ulcer is thought to depend on host genetics, but very few genetic studies have been performed. The identification of a microdeletion on chromosome 8 in a familial form of severe Buruli ulcer suggested a monogenic basis of susceptibility. The role of common host genetic variants in Buruli ulcer development has been investigated in only three candidate-gene studies targeting genes involved in mycobacterial diseases. A recent genome-...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
This study systematically reviewed and conducted a meta-analysis for all research aimed at developing cell-mediated immunity (CMI) and/or serology-based tests forM.ulcerans disease. Information for this review was searched through PubMed and Web of Science databases and identified up to June 2019. References from relevant articles and reports from the WHO Annual Meeting of the Global Buruli Ulcer Initiative were also used. Twelve studies beginning in 1952, that attempted to develop CMI and/or serology-based tests for the disease were identified. These studies addressed issues of specificity and sensitivity in context of an...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Hellen Weinschutz Mendes, Angelica Winter Boldt, Ewalda Stahlke, Jens Christian Jensenius, Steffen Thiel, Iara J. Taborda Messias-Reason BackgroundDeposition of complement factors onMycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement. Three proteins of the lectin pathway are produced from the geneMASP1: Mannan-binding lectin-associated serine protease 1 (MASP-1) and MASP-3 and mannan-binding lectin-associated protein of 44 kDa (MAp44). Despite their obvious importance, the roles played by these proteins have never been investigated in leprosy disease. Methodo...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Conclusion: New deformities continue to develop in certain forms of leprosy even after release from treatment. Long-term&regular follow up of patients who have been released from treatment is required.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Abstract This ecological study aims to analyze both the tendency and the characteristics of leprosy in the elderly population in the state of Bahia, 2001-2017. The tendency was analyzed through joinpoint regression. Epidemiological variables were also included in the study. The average detection rate was 38.73/100,000, with prevalence of men (45.19/100,000). A downward trend occurred in both genders, from 2004, with a greater magnitude in women (annual percent change [APC] = − 3.4%). Men presented higher proportions of the multibacillary forms and physical disabilities. The epidemiological scenario indicates the need...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
S. T. Chambers et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
ps PD Abstract Deformities of bones of the face and extremities are markers of leprosy (Hansen's disease) which contribute to stigma associated with this disease. Among these deformities are articular alterations that can mimic rheumatoid arthritis (RA). In this case, a 64-year-old man presented with a history of having been treated for lepromatous leprosy and erythema nodosum leprosum episodes, which evolved with joint alterations similar to those of RA. Most cases of leprosy-related arthritis are associated with reactional episodes, of which a large number do not respond to conventional therapy for leprosy react...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
by Robertha Mariana R. Lemes, Carlos Adriano de M. e Silva, Maria Ângela de M. Marques, Georgia C. Atella, José Augusto da C. Nery, Maria Renata S. Nogueira, Patricia S. Rosa, Cléverson T. Soares, Prithwiraj De, Delphi Chatterjee, Maria Cristina V. Pessolani, Cristiana S. de Macedo The changes in host lipid metabolism during leprosy have been correlated to fatty acid alterations in serum and with high-density lipoprotein (HDL) dysfunctionality. This is most evident in multibacillary leprosy patients (Mb), who present an accumulation of host lipids in Schwann cells and macrop hages. This accumulation in...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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