DNA interaction studies of rhenium compounds with Schiff base chelates encompassing biologically relevant moieties.

DNA interaction studies of rhenium compounds with Schiff base chelates encompassing biologically relevant moieties. Nucleosides Nucleotides Nucleic Acids. 2019 Jul 10;:1-22 Authors: Ismail MB, Booysen IN, Akerman MP Abstract Herein, we report the DNA interaction studies of rhenium(I) and -(V) compounds with Schiff base chelates encompassing biologically relevant moieties. More specifically, the DNA interaction capabilities of these rhenium complexes were probed using Gel Electrophoresis and Calf Thymus-DNA titrations monitored by temperature-controlled electronic spectroscopy. The DNA binding modes of the metal compounds were corroborated by molecular docking simulations. In addition, the synthesis and characterization of a novel facial tricarbonyl rhenium(I) compound, fac-[Re(chrs)(CO)3Br], (chrs = {3-{[(2-hydroxyphenyl)imino]methyl}-4H-chromen-4-one) are reported. PMID: 31290374 [PubMed - as supplied by publisher]
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research