Prediction of Survival in Children With Cystic Fibrosis Using the Multiple-breath Washout

Conditions:   Cystic Fibrosis;   Death;   Lung Transplantation Intervention:   Diagnostic Test: Lung function testing Sponsors:   University Hospital Inselspital, Berne;   Lindenhofspital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Lung transplantation is an established therapeutic option for patients with irreversible end-stage pulmonary disease limiting life expectancy and quality of life. Common indications for lung transplantation include chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension, and alpha-1 antitrypsin deficiency. Complications of lung transplantation can be broadly divided etiologically into surgical, infectious, immunologic, or neoplastic. Moreover, specific complications often occur within a certain time interval following surgery, which can be broadly classified as...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Review Articles Source Type: research
BackgroundThere is a paucity of data evaluating antibiotic use in anterior skull ‐base surgery (ASBS). The goal of this study was to determine antibiotic prescribing patterns and factors that influence antibiotic use in ASBS.MethodsAn online ‐based survey was distributed to the membership of the North American Skull Base Society in 2018. Outcomes included practitioner preference regarding intraoperative and postoperative antibiotic use, practice location and environment, surgeon experience, and patient factors influencing antibiotic u se.ResultsThere were 208 respondents (25.6% response rate) of which 182 (87.5%) perfo...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Nieborak-Raczkowska M, Kubisa B, Piotrowska M, Grodzki T, Kubisa A, Pieróg J, Wojtyś M, Bielewicz M, Czarnecka M, Wójcik J, Wójcik N, Sielicki W, Brykczyński M PMID: 31410098 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutrition and chronic disease I Source Type: research
Abstract Sickle cell disease afflicts millions of people worldwide and approximately 100,000 Americans. Complications are myriad and arise as a result of complex pathological pathways 'downstream' to a point mutation in DNA, and include red blood cell membrane damage, inflammation, chronic hemolytic anemia with episodic vaso-occlusion, ischemia and pain, and ultimately risk of cumulative organ damage with reduced patient lifespan. The National Heart, Lung, and Blood Institute's 2014 evidence-based guideline for sickle cell disease -management states additional research is needed before investigational curative the...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
A 30-year-old cystic fibrosis (CF) male with recurrent multi-drug resistant Burkholderia multivorans infections developed persistent bacteremia, despite high-dose antibiotics for>10 days, and ventilator as well as venovenous (VV) extracorporeal membrane oxygenation (ECMO) dependence limiting his transplant candidacy.1,2 No non-pulmonary sources of infection were identified; his chest radiograph demonstrated significant pulmonary disease. We performed bilateral pneumonectomies to clear his infection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
Publication date: Available online 7 August 2019Source: Genes &DiseasesAuthor(s): Jhumki Das, Avinash Sharma, Ankur Jindal, Vaishali Aggarwal, Amit RawatAbstractMigration of polymorphonuclear leukocytes from bloodstream to the site of inflammation is an important event required for surveillance of foreign antigens. This trafficking of leukocytes from bloodstream to the tissue occurs in several distinct steps and involves several adhesion molecules. Defect in adhesion of leukocytes to vascular endothelium affecting their subsequent migration to extravascular space gives rise to a group of rare primary immunodeficiency d...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
ConclusionsTen ‐year survivors were significantly younger, weighed less, and had significantly shorter lengths of hospitalization after transplantation. Bilateral lung transplantation was a significant factor in prolonged survival. Survival also improved with institutional experience
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
The increasing life expectancy of individuals with Cystic Fibrosis (CF) is likely to be associated with new age-related challenges, colorectal cancer (CRC) most notably; recent consensus recommendations for CRC s...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Case report Source Type: research
PMID: 31356757 [PubMed - as supplied by publisher]
Source: Am J Respir Crit Car... - Category: Intensive Care Authors: Tags: Am J Respir Crit Care Med Source Type: research
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