MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels

Sick sinus syndrome (SSS) is primarily a disease of the elderly, and age-dependent decrease in Cav1.2 and Cav1.3 Ca2+ channels within the sinus node has been shown to play an important role in sinoatrial node (SAN) degeneration; however, posttranscriptional mechanisms regulating decrease in Cav1.2 and Cav1.3 Ca2+ channels remain unclear. Some studies have reported that microRNAs (miRNAs) are involved in age-related cardiovascular diseases. Nevertheless, little is known about the roles of miRNAs in age-related SSS.

Source: Journal of Molecular and Cellular Cardiology - July 10, 2019 Category: Cytology Authors: Jin Zhang, Feiyu Wei, Liqun Ding, Lilin Wang, Xi Zhang, Lin Yu, Rui Liu, Xiaohui Kuang, Baowei Jiao, Bin Yang, Jie Fan Source Type: research