Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress.

In conclusion, Plin5 deficiency increases myocardial lipolysis, elevates FAO and oxidative burden, and thereby exacerbates cardiac hypertrophy and heart failure in TAC-treated mice. PMID: 31291602 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31291602?dopt=Abstract

Source: Free Radical Biology and Medicine - July 6, 2019 Category: Biology Authors: Wang C, Yuan Y, Wu J, Zhao Y, Gao X, Chen Y, Sun C, Xiao L, Zheng P, Hu P, Li Z, Wang Z, Ye J, Zhang L Tags: Free Radic Biol Med Source Type: research