Response to Comment on "Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality"

Thakkar and McCarthy suggest that periodicity in measles incidence artifactually drives our estimates of a 2- to 3-year duration of measles "immune-amnesia." We show that periodicity has a negligible effect relative to the immunological signal we detect, and demonstrate that immune-amnesia is largely undetectable in small populations with large fluctuations in mortality of the type they use for illustration.
Source: ScienceNOW - Category: Science Authors: Tags: Medicine, Diseases t-comment Source Type: news

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In this study, we examined the effect of PEG-AM on four-vessel occlusion model rats, which exhibit vascular dementia. From day 10 to day 14 after surgery, the learning and memory abilities of the rats were examined using a Morris water maze. The rats were treated with a single subcutaneous injection of 1.0 or 10.0 nmol/kg of PEG-AM. PEG-AM treatment reduced the escape latency in the hidden platform test. Furthermore, the treatment increased the time spent in the platform quadrant in the probe test. The data showed that PEG-AM injection prevented memory loss and learning disorders in dose-dependent manner. On day 14,...
Source: Peptides - Category: Biochemistry Source Type: research
Publication date: 24 August 2019Source: New Scientist, Volume 243, Issue 3244Author(s): Staff and agencyThree years after the virus was eliminated from the country, the UK has lost its “measles-free” status
Source: New Scientist - Category: Science Source Type: research
A teenage girl from New Zealand sick with measles visited Disneyland and other popular tourist stops across Southern California earlier this month, possibly infecting others, local government health officials warned.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
00:44 | Measles&Immune Amnesia09:16| Sponsored by HAPS09:44 | Bone Growth Update13:55 | Sponsored by AAA14:27 |Featured: The Wallenda Model of Homeostasis40:43 |  Sponsored by HAPI Online Graduate Program41:32 | Hearing from YOUIf you cannot see or activate the audio playerclick here. Questions&Feedback:1-833-LION-DEN (1-833-546-6336) FollowThe A&P Professor onTwitter,Facebook,Blogger,Nuzzel,Tumblr, orInstagram! After nourishment, shelter, and companionship, stories are the thing we need most in the world. (Philip Pullman) 1 | Measles and Immune Amnesia8.5 minutesMeasles (MV) is very c...
Source: The A and P Professor - Category: Physiology Authors: Source Type: blogs
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
One of the main causes of health care dysfunction identified by demoralized health care professionals in our 2003 qualitative study was threats to evidence-based medicine, and by extension, evidence-based public health and health policy.(1) Since then, we have frequently discussed threats such asmanipulation andsuppression of clinical research to further vested interests, and distortion of research dissemination, such asghost written articles, often enabled byindividual andinstitutional conflicts of interest.These and other causes of health care dysfunction which we discuss, however, have hardly been the stuff of political...
Source: Health Care Renewal - Category: Health Management Tags: asbestos Donald Trump evidence-based medicine health policy public health Source Type: blogs
Conclusion A growing number of today’s children suffer from vaccine damage. Most individuals do not make the connection between health problems and vaccines. When asked about the cause of autoimmune disorders, asthma, allergies, diabetes, learning disabilities, attention deficit disorder, autism, and other common childhood diseases and illness, the majority of health care providers advise patients that the causes are unknown. Doctors, including most integrative physicians, fail to make the connection to vaccines. It takes one moment to permanently damage the health of an adult or child, but t...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Stories autoimmune disorders gardasil HPV Vaccine Medical Authority vaccine injury Source Type: blogs
Can you tell me what the term "immune amnesia" means? I've heard that having measles erases the immune system's memory of earlier infections, leaving kids vulnerable to ones they've already had.
Source: Dr. Weil Q and A - Category: Consumer Health News Source Type: news
If there were ever any doubt that measles is a dangerous disease, a study published in the journal Science yesterday blows that misconception away by finally explaining how large-scale measles vaccination caused such a plummet in childhood deaths – even from infections that seemed unrelated to measles.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Immunosuppression after measles is known to predispose people to opportunistic infections for a period of several weeks to months. Using population-level data, we show that measles has a more prolonged effect on host resistance, extending over 2 to 3 years. We find that nonmeasles infectious disease mortality in high-income countries is tightly coupled to measles incidence at this lag, in both the pre- and post-vaccine eras. We conclude that long-term immunologic sequelae of measles drive interannual fluctuations in nonmeasles deaths. This is consistent with recent experimental work that attributes the immunosuppressive ef...
Source: Science: Current Issue - Category: Science Authors: Source Type: research
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