Frequency-dependent responses of neuronal models to oscillatory inputs in current versus voltage clamp.

Frequency-dependent responses of neuronal models to oscillatory inputs in current versus voltage clamp. Biol Cybern. 2019 Jul 08;: Authors: Rotstein HG, Nadim F Abstract Action potential generation in neurons depends on a membrane potential threshold and therefore on how subthreshold inputs influence this voltage. In oscillatory networks, for example, many neuron types have been shown to produce membrane potential ([Formula: see text]) resonance: a maximum subthreshold response to oscillatory inputs at a nonzero frequency. Resonance is usually measured by recording [Formula: see text] in response to a sinusoidal current ([Formula: see text]), applied at different frequencies (f), an experimental setting known as current clamp (I-clamp). Several recent studies, however, use the voltage clamp (V-clamp) method to control [Formula: see text] with a sinusoidal input at different frequencies [[Formula: see text]] and measure the total membrane current ([Formula: see text]). The two methods obey systems of differential equations of different dimensionality, and while I-clamp provides a measure of electrical impedance [[Formula: see text]], V-clamp measures admittance [[Formula: see text]]. We analyze the relationship between these two measurement techniques. We show that, despite different dimensionality, in linear systems the two measures are equivalent: [Formula: see text]. However, nonlinear model neurons produce different values for Z a...
Source: Biological Cybernetics - Category: Science Authors: Tags: Biol Cybern Source Type: research