Pedigree relationships to control inbreeding in optimum-contribution selection realise more genetic gain than genomic relationships.

CONCLUSIONS: POCS realised more true genetic gain than GOCS because it managed expected genetic drift without restricting selection at QTL. By contrast, GOCS penalised changes in allele frequencies at markers that were generated by genetic drift and selection. Because these marker alleles were in linkage disequilibrium with QTL alleles, GOCS restricted changes in allele frequencies at QTL. This provides little incentive to use GOCS and highlights that we have more to learn before we can control inbreeding using genomic relationships in selective-breeding schemes. Until we can do so, POCS remains a worthy method of optimum-contribution selection because it realises more true genetic gain than GOCS at the same rate of true inbreeding.
PMID: 31286868 [PubMed - in process]

Source: Genet Sel Evol - July 7, 2019 Category: Genetics & Stem Cells Authors: Henryon M, Liu H, Berg P, Su G, Nielsen HM, Gebregiwergis GT, Sørensen AC Tags: Genet Sel Evol Source Type: research