The therapeutic potential of small activating RNAs for colorectal carcinoma.

The therapeutic potential of small activating RNAs for colorectal carcinoma. Curr Gene Ther. 2019 Jul 08;: Authors: Zheng B, Mai QY, Jiang JX, Zhou QQ Abstract Small double strand RNA has been recognized as master regulator of gene expression. In contrast to the evolutionary conserved RNA interference machinery, which degrades or inhibits the translation of target mRNAs, the RNA activation is a gene regulation mechanism that facilitates the exact opposite effect. It is triggered by double strand RNA termed small activating RNA and acts through a similar mechanism as RNAi, while activates the specific gene on a target dependent manner. Recently, small RNA molecule mediated expression regulation of specific genes has been extensively studied in the cancer researches. Of particular interest is the application of the RNA mediated gene activation within the colorectal cancer (CRC) development, due to the high incidence of the CRC. In this review, we summarize the current knowledge of saRNA mediated genetic activation and its underlying mechanisms. Furthermore, we highlight the advantages of the utilization of saRNAs induced gene expression, particular as an investigating tool in colorectal cancer research. Finally, the possibility and the challenge of the saRNA application as a potential therapy for the colorectal cancer are addressed. PMID: 31284860 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research