Functional Immunoregulation by Heme Oxygenase 1 in Juvenile Autoimmune Diseases.

Functional Immunoregulation by Heme Oxygenase 1 in Juvenile Autoimmune Diseases. Curr Gene Ther. 2019 Jul 09;: Authors: Zhang X, Shi S, Shen J, Zhao M, He Q Abstract Autoimmune disease is an inflammatory disease in which the human body's autoimmune system attacks normal cells, resulting in decreased immune function and abnormal immune function, which eventually leads to tissue damage or organ dysfunction. It is estimated that 5-8% of the world's population is at risk of autoimmune diseases. In the field of medicine, especially in pediatrics, the research data of autoimmune diseases are still insufficient. Some prevalent juvenile autoimmune diseases, such as schoenlein-henoch purpura (HSP), systemic juvenile idiopathic arthritis (SJIA), mucocutaneous lymph node syndrome (MCLS) and autoimmune encephalitis (AE) arouse considerable public concern. A number of recent studies found that heme oxygenase-1 (HO-1), an enzyme that functions in heme degradation, presents a critical role in pathogenesis and may function in regulating the autoimmune system. Firstly, it could promote the differentiation of T lymphocyte to CD4+CD25+ Treg and may have an association with the varied proportion of Th1/Th2 and Th17/Treg cytokines as well. Secondly, HO-1 is prove to function in regulating the immune system through the secretion of cytokines such as TGF and IL. Moreover, increasing the expression of HO-1 can also improve vascular function by increasing an...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research