Lynch syndrome in urologic malignancies – what does the urologist need to know?

Lynch Syndrome (LS) entails a defective DNA mismatch repair system, which is the post-replicative proofreading and editing system, ensuring our genome's integrity. LS predisposes to several cancers, most commonly colorectal and endometrial cancers. LS occurs in approximately 1 in 250 –1,000 people.LS is associated with urological malignancies with upper tract urothelial carcinoma the most common, although still clinically underestimated. Other urologic malignancies possibly associated with LS include bladder, prostate, testis, and renal cell carcinoma.

Source: Urology - July 10, 2019 Category: Urology & Nephrology Authors: Hanan Goldberg, Christopher J.D. Wallis, Zachary Klaassen, Thenappan Chandrasekar, Neil Fleshner, Alexandre R. Zlotta Source Type: research