Children born to obese mothers are 57% more likely to develop cancer, study finds

The researchers, who analyzed millions of birth and cancer records in Pennsylvania, said disruptions to insulin levels may trigger dangerous cell changes that lead to disease years later.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 18 July 2019Source: The American Journal of SurgeryAuthor(s): Brigid K. Killelea, Emily J. Gallagher, Sheldon M. Feldman, Elisa Port, Tari King, Susan K. Boolbol, Rebeca Franco, Kezhen Fei, Derek Le Roith, Nina A. BickellAbstractIntroductionAlthough breast cancer incidence is higher among white women, black women are more likely to have aggressive tumors with less favorable histology, and to have a worse prognosis. Obesity and alcohol consumption have been identified as two modifiable risk factors for breast cancer, while physical activity may offer protection. Little however is known abo...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Introduction: Life expectancy in women with breast cancer (BC) is 80% at 5 years. Age, medications, obesity, metabolic syndrome and diabetes increase cardiovascular risk. The Mediterranean diet (MeD) and low glycemic index (GI) diets, nevertheless, are protective. Therefore, we evaluated the effect of low-GI Mediterranean diet on cardiovascular risk factors in women treated for BC.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
DiscussionThe rising corpus uteri cancer incidence in Estonia is driven by the type I cancer trend. Survival gain for later stages and older age groups likely reflected more frequent surgical treatment. To reduce mortality, further efforts are necessary to ensure appropriate care for all patients.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
AbstractThe field of thyroid hormone signaling has grown more complex in recent years. In particular, it has been suggested that some thyroid hormone derivatives, tentatively named “novel thyroid hormones” or “active thyroid hormone metabolites”, may act as independent chemical messengers. They include 3,5-diiodothyronine (T2), 3-iodothyronamine (T1AM), and several iodothyroacetic acids, i.e., 3,5,3’,5’-thyroacetic acid (TA4), 3,5,3’-thyroacetic acid (TA3), and 3 -thyroacetic acid (TA1). We summarize the present knowledge on these compounds, namely their biosynthetic pathways, endo...
Source: Endocrine - Category: Endocrinology Source Type: research
Authors: Zhao L, Huang H, Zhao D, Wang C, Tian Y, Yuan X, Ma F, Ren H, Zhao Y, Aimaiti S, Zhang S, Zhou H, Wang T, Wang N, Sun Y, Bai X, Chen Y Abstract Background: The prognostic relevance of gastric tumor location has been reported and debated. Our study was conducted to examine the differences in clinicopathological features, prognostic factors, and overall survival (OS) between patients with proximal gastric cancer (PGC) and distal gastric cancer (DGC). Patients and Methods: Patients with PGC or DGC were identified from the China National Cancer Center Gastric Cancer Database (NCCGCDB) during 1997-2017. Sur...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Abstract A significant obstacle to the study of human cancer biology and the testing of human specific immunotherapeutics is the paucity of translational models that recapitulate both the growth of human tumors and the functionality of human immune systems. Humanized mice engrafted with human hematopoietic stem cells (HSC) and patient-derived xenografts (PDX) enable preclinical investigation of the interactions between the human immune system and human cancer. We use immunodeficient non-obese diabetic (NOD, scid, gamma) NSG™ or NSG™-SGM3 mice as hosts for establishment of human immunity following HSC i...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Contributors : Wan Y Yang ; Pei S Rao ; Yong C Luo ; Hua K Lin ; Sing H Huang ; Jinn M Yang ; Chiou H YuhSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPrevious studies have identified liver cancer associated to NASH, diabetes, obesity, and some genetic risk factors. We want to investigate the synergism between diet and genetic risk factors in hepatocarcinogenesis using omics data of four background zebrafish in three types of diet. We found the fishes have more genetic risk factors at the same time, and have higher probability to accelerate cancer formation. Overfed and high fat diet...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Contributors : Wan Y Yang ; Pei S Rao ; Yong C Luo ; Hua K Lin ; Sing H Huang ; Jinn M Yang ; Chiou H YuhSeries Type : Expression profiling by arrayOrganism : Danio rerioPrevious studies have identified liver cancer associated to NASH, diabetes, obesity, and some genetic risk factors. We want to investigate the synergism between diet and genetic risk factors in hepatocarcinogenesis using omics data of four background zebrafish in three types of diet. We found the fishes have more genetic risk factors at the same time, and have higher probability to accelerate cancer formation. Overfed and high fat diet will increase the ch...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Danio rerio Source Type: research
As awful for health as they are, having played such a huge role in childhood breakfasts, thoughts of breakfast cereals still conjure up a host of memories. Deep within the haze of my childhood memories, buried beneath recollections of nerdy high school days, a marriage gone sour, and a brother-in-law midlife crisis involving duct tape, three members of the local PTA, and a VW bus, are images of the mornings I sat with my two sisters at our kitchen table in suburban New Jersey, each of us slurping a bowl of Trix, Lucky Charms, or Fruit Loops cereal, still recovering from a late night of Bewitched and Mission Impossible. We ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Breakfast cereal grain-free wheat belly Source Type: blogs
(The Translational Genomics Research Institute) Researchers have found that a gene known as AEBP1 may play a central role in the development, severity and potential treatment of liver disease, according to a study by Temple University, the Geisinger Obesity Institute and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. One of the study's major findings is that AEBP1 regulates the expression of a network of at least nine genes related to fibrosis: AKR1B10, CCDC80, DPT, EFEMP1, ITGBL1, LAMC3, MOXD1, SPP1, and STMN2.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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