Woman who had two liver transplants and was told she'd NEVER have kids gives birth to baby girl  

Hannah Rosenfelder, 29, from Broomfield, Colorado, had her first liver transplant at age 15 and her second transplant at age 25. She gave birth to her daughter, Hadley, in October 2017.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Bai H, Wen J, Gong JP, Wu H, Yuan FC, Cao D, Wu YK, Lai X, Wang MH Abstract Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver tissues. The vital role of Notch1/Jagged1 pathway in mouse OLT model has been reported, however, its potential therapeutic mechanism is unknown. Here, we made use of short hairpin RNA-Jagged1 and AAV-Jagged1 to explore the effects of Not...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Source: Gastroenterology - Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activity Source Type: research
Conditions:   Complication, Postoperative;   Regeneration Liver Intervention:   Drug: Potassium Phosphate Injection Sponsor:   Institute of Liver and Biliary Sciences, India Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: de la Fuente S, Citores MJ, Lucena JL, Muñoz P, Cuervas-Mons V Abstract Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients &methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9 -1237C/T and -1486C/T polymorphisms were analyzed by real-time PCR and melting curves analysis. Results: 20 of 159 patients (12.6%) developed post-transplant HCC recurrence. Tumors exceeding Milan criteria, moderately-to-poorly differenti...
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Li M, Lu C, Zhu H, Kang X, Wang F, Shao L, Lu X, Chen W, Xia X Abstract Acute graft-versus-host disease (aGVHD) is one of the major complications after liver transplantation (LTx), which is induced by over-activation of T helper lymphocytes. Cenicriviroc (CVC) exerts its anti-inflammatory effect through inhibition of C-C chemokine receptor 5 (CCR5). However, whether CVC ameliorates aGVHD after liver transplantation remains unknown. In the present study, a rat aGVHD liver transplantation model (LTx-aGVHD) was constructed. CVC was intravenously injected from day 7 to day 14 after LTx. Liver and intestine sam...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Schielke A, Meurisse N, Lamproye A, Honoré P, Delwaide J, Hustinx R, Detry O Abstract Ever since the initial description of the Milan criteria, used for selecting patients with hepatocellular carcinoma (HCC) for liver transplantation (LT), there has been a clear need to go further than solely morphological criteria. Tumours exceeding the Milan criteria, but presenting favourable biological behaviour, might still allow for comparable overall- and disease-free survivals after LT. As it is well established that the presence of microvascular invasion is a major factor that influences HCC recurrence afte...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Authors: Verhelst X, Geerts A, Callewaert N, Van Vlierberghe H Abstract The study of glycomics is a novel and fascinating approach for the development of biomarkers. It has become clear that in the field of liver disease specific glycomic patters are present in specific disease states, which has led to the development of diagnostic biomarkers. In this manuscript, we will describe two new applications of this technology for the development of prognostic biomarkers. The first biomarker is associated with the risk of hepatocellular carcinoma development in patients with compensated cirrhosis. The second biomarker is p...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Cirrhosis is a life-threatening condition and a major cause of morbidity and mortality worldwide. Improvement in the management of its related complications, of its aetiologies (i.e. viral eradication), and the option of liver transplantation have increased life expectancy of patients with cirrhosis. In this setting, it is not unusual that patients with cirrhosis are proposed for major surgical procedures for orthopaedic, malignancy or cirrhosis related complications. In fact, patients with cirrhosis have a high incidence of gallstones and abdominal wall hernias that require surgical repair[1 –4].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Semin Liver Dis DOI: 10.1055/s-0039-1693513The unique ability of the adult liver to regenerate after injury is the basis for efficient surgical resection and liver transplantation and provides solutions for the treatment of liver cancer and acute liver failure. Current success in surgical treatments could be enhanced by directed regulation of liver regeneration. A number of small molecules and growth factors have been tested in mice models to improve liver regeneration. Noncoding ribonucleic acids (ncRNA) are less studied regulators of various cellular processes. Here, the authors carefully review ncRNA involved in liver r...
Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
Condition:   Liver Transplantation Intervention:   Device: Liver Machine Perfusion (MP) device Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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