Association Between Bilirubin, Atazanavir, and Cardiovascular Disease Events Among People Living With HIV Across the United States

We examined these associations in people living with HIV (PLWH). Methods: Potential myocardial infarctions (MIs) and strokes were centrally adjudicated. We examined MI types: type 1 MI (T1MI) from atherosclerotic plaque instability and type 2 MI (T2MI) in the setting of oxygen demand/supply mismatch such as sepsis. We used multivariable Cox regression analyses to determine associations between total bilirubin levels and outcomes adjusting for traditional and HIV-specific risk factors. To minimize confounding by hepatobiliary disease, we conducted analyses limited to bilirubin values
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Epidemiology Source Type: research

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Publication date: Available online 15 July 2019Source: Journal of Theoretical BiologyAuthor(s): Hugh Z. Ford, Helen M. Byrne, Mary R. MyerscoughAbstractAtherosclerosis is a chronic inflammatory disease driven by the accumulation of pro-inflammatory, lipid-loaded macrophages at sites inside artery walls. These accumulations lead to the development of atherosclerotic plaques. The rupture of plaques that contain lipid-rich necrotic cores can trigger heart attacks and strokes via occlusion of blood vessels. We construct and analyse a system of partial integro-differential equations that model lipid accumulation by macrophages,...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Authors: Tao D, Liu F, Sun X, Qu H, Zhao S, Zhou Z, Xiao T, Zhao C, Zhao M Abstract Stroke often leads to neuronal injury and neurological functional deficits. Whilst spontaneous neurogenesis and axon regeneration are induced by ischemic stroke, effective pharmacological treatments are also essential for the improvement of neuroplasticity and functional recovery after stroke. However, no pharmacological therapy has been demonstrated to be able to effectively improve the functional recovery after stroke. Bumetanide is a specific Na +-K +-Cl- co-transporter inhibitor which can maintain chloride homeostasis ...
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
Initiating stroke treatment just 15 minutes faster can save lives and prevent disability, according to a new UCLA-led study, published today inJAMA. The research also determined that busier hospitals — those that treat more than 450 people for stroke each year — have better outcomes than those that treat fewer than 400 stroke patients per year.Researchers at the  David Geffen School of Medicine at UCLA and five other institutions in the U.S. and Canada, examined data for 6,756 people who experienced ischemic strokes. The patients ’ median age was 71, and 51.2% were women.The researchers looked at str...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Conditions:   Visual Fields Hemianopsia;   Stroke, Ischemic;   Stroke Hemorrhagic Interventions:   Device: High frequency repetitive transcranial magnetic stimulation (rTMS);   Device: Sham stimulation Sponsor:   Ain Shams University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Brain Injuries;   Stroke Intervention:   Device: Head protection prototype device Sponsor:   Tan Tock Seng Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Acute Ischemic Stroke;   Abnormal Glucose Metabolism Intervention:   Drug: Urinary Kallidinogenase Sponsor:   The Second Hospital of Hebei Medical University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions/Implications for Practice These results indicate that the T-SSEQ is acceptable for use with Turkish stroke patients in both practice and research settings. Furthermore, the questionnaire is suitable for nurses to use in designing interventions and evaluating stroke patients' self-efficacy in clinics, home care, and rehabilitation centers.
Source: Journal of Nursing Research - Category: Nursing Tags: ORIGINAL ARTICLES Source Type: research
Conclusion: Our results suggested that activation of the non-lesional hemisphere in sub-acute stroke associated with motor recovery in moderate-to-severe upper limb hemiparesis. A multidisciplinary rehabilitation of stroke patients with moderate-to-severe upper limb hemiparesis might enhance the compensatory movements and pre-existing motor network from the non-lesional motor cortex.
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Remote ischemic preconditioning (RIPC) is an effective regimen for neuroprotection in ischemic stroke. Exosomes are extracellular vesicles released into the blood, where they can transfer signals throughout the body. Several studies have demonstrated that RIPC leads to many changes in circulating exosomes. However, the role of RIPC-induced exosomes in neuroprotection remains to be determined. In the current study, we demonstrate that infusion of enriched plasma exosomes from RIPC-treated mice significantly attenuates infarction size in a murine model of cerebral ischemia compared to control group receiving infusion of exos...
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research
Authors: Drakopoulou M, Oikonomou G, Soulaidopoulos S, Toutouzas K, Tousoulis D Abstract Introduction: Ideal management of concomitant carotid and coronary artery occlusive disease remains under investigation. Although researchers have advocated the potential benefits of varying treatment strategies based on either concomitant or staged surgical treatment, there is no consensus in treatment guidelines among national or international clinical societies. With emerging data suggesting favorable outcome of carotid artery stenting (CAS) compared to carotid endarterectomy (CEA) in patients with critical coronary artery d...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
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