NIH scientists identify spasm in women with endometriosis-associated chronic pelvic pain

Small study suggests botulinum toxin may be potential treatment.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news

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A 38-year-old woman presented with chronic pelvic pain. She reported an extensive surgical history focused primarily on treatment of endometriosis of unknown stage and her pelvic pain. This included total hysterectomy and bilateral salpingectomy subsequently followed by bilateral-oophorectomy 3 years prior. Following her surgical menopause, she underwent six additional robotically assisted procedures during a 3 year period of time which involved fulguration of endometriosis. She denied having had any prior excisional procedures performed.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: AGES IN Gynecological Surgery Source Type: research
ConclusionQualitative research has the potential to reveal and explain several aspects of CPP in women. The medical community may better accept knowledge gained from these studies if the methods are described more transparently in published articles.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Conditions:   Pain, Chronic;   Pain, Pelvic;   Pain, Abdominal;   Depression;   Sex Disorder;   Endometriosis Intervention:   Behavioral: Learning of Coping Strategies Sponsor:   Swiss Paraplegic Centre Nottwil Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Chronic pelvic pain is common and is estimated to affect over one million women in the UK. It may be a symptom of a number of different conditions and is often multifactorial in nature, caused by a combination of physical, psychological and social factors. For many women, a primary cause cannot be identified. This can make  both diagnosis and management difficult. Gynaecological causes of chronic pelvic pain include endometriosis, chronic pelvic inflammatory disease and adhesions. The gynaecologist must also consider non-gynaecological causes of pain related to the gastrointestinal, urinary, neurological, musculoskel ...
Source: Obstetrics, Gynaecology and Reproductive Medicine - Category: OBGYN Authors: Tags: Review Source Type: research
Source: International Journal of Womens Health - Category: OBGYN Tags: International Journal of Women's Health Source Type: research
Abstract Endometriosis is a potentially life altering, oestrogen-dependent, condition, which is associated with chronic pelvic pain. It affects an estimated 176 million women worldwide, making it as common as diabetes mellitus (DM). PMID: 31359584 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
ConclusionLaparoscopic reverse technique is an alternative approach to face retrocervical or rectovaginal nodules infiltrating the anterior rectal wall.  In this technique, the separation of the nodule from the rectal wall is performed at the end of the surgery and not at the beginning as performed within the traditional technique. This enables the surgeon to perform a more precise dissection of the endometriotic nodule from the rectal wall because of the increased mobility of the bowel. The wider range of movements serves as an ergonomic advantage for the subsequent dissection of the lesion from the rectum, allowing ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 29 June 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Alexander Kotlyar, Hugh Taylor, Thomas D'HoogheAbstractBoth animal and human studies have demonstrated that endometriosis involves numerous levels of immune dysfunction. From aberrant cytokine signaling to shifts in immune cell populations, it is clear that endometriosis develops in the setting of an elevated pro-inflammatory state. This elevated level of inflammation could exacerbate the morbidity seen in this chronic disease. Consequently, numerous immunomodulating therapies have been tested i...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Conditions:   Endometriosis;   Chronic Pain;   Quality of Life Interventions:   Device: Radiofrequency A;   Device: Radiofrequency B Sponsor:   Hospital Clinic of Barcelona Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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