NIH scientists identify spasm in women with endometriosis-associated chronic pelvic pain
Small study suggests botulinum toxin may be potential treatment.
A 38-year-old woman presented with chronic pelvic pain. She reported an extensive surgical history focused primarily on treatment of endometriosis of unknown stage and her pelvic pain. This included total hysterectomy and bilateral salpingectomy subsequently followed by bilateral-oophorectomy 3 years prior. Following her surgical menopause, she underwent six additional robotically assisted procedures during a 3 year period of time which involved fulguration of endometriosis. She denied having had any prior excisional procedures performed.
ConclusionQualitative research has the potential to reveal and explain several aspects of CPP in women. The medical community may better accept knowledge gained from these studies if the methods are described more transparently in published articles.
Conditions: Pain, Chronic; Pain, Pelvic; Pain, Abdominal; Depression; Sex Disorder; Endometriosis Intervention: Behavioral: Learning of Coping Strategies Sponsor: Swiss Paraplegic Centre Nottwil Not yet recruiting
Chronic pelvic pain is common and is estimated to affect over one million women in the UK. It may be a symptom of a number of different conditions and is often multifactorial in nature, caused by a combination of physical, psychological and social factors. For many women, a primary cause cannot be identified. This can make both diagnosis and management difficult. Gynaecological causes of chronic pelvic pain include endometriosis, chronic pelvic inflammatory disease and adhesions. The gynaecologist must also consider non-gynaecological causes of pain related to the gastrointestinal, urinary, neurological, musculoskel ...
Abstract Endometriosis is a potentially life altering, oestrogen-dependent, condition, which is associated with chronic pelvic pain. It affects an estimated 176 million women worldwide, making it as common as diabetes mellitus (DM). PMID: 31359584 [PubMed - as supplied by publisher]
ConclusionLaparoscopic reverse technique is an alternative approach to face retrocervical or rectovaginal nodules infiltrating the anterior rectal wall. In this technique, the separation of the nodule from the rectal wall is performed at the end of the surgery and not at the beginning as performed within the traditional technique. This enables the surgeon to perform a more precise dissection of the endometriotic nodule from the rectal wall because of the increased mobility of the bowel. The wider range of movements serves as an ergonomic advantage for the subsequent dissection of the lesion from the rectum, allowing ...
Publication date: Available online 29 June 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Alexander Kotlyar, Hugh Taylor, Thomas D'HoogheAbstractBoth animal and human studies have demonstrated that endometriosis involves numerous levels of immune dysfunction. From aberrant cytokine signaling to shifts in immune cell populations, it is clear that endometriosis develops in the setting of an elevated pro-inflammatory state. This elevated level of inflammation could exacerbate the morbidity seen in this chronic disease. Consequently, numerous immunomodulating therapies have been tested i...
Conditions: Endometriosis; Chronic Pain; Quality of Life Interventions: Device: Radiofrequency A; Device: Radiofrequency B Sponsor: Hospital Clinic of Barcelona Recruiting