Behavioural effects of high fat diet exposure starting in late adolescence in neuregulin 1 transmembrane domain mutant mice.

In conclusion, HFD exposure starting in late adolescence has sex-specific effects on exploration and fear-associated memory, which was less pronounced in females mutant for Nrg1. This suggests that research into the role of diets in schizophrenia-relevant domains should consider genetic risk factors for the disease as schizophrenia risk genes such as Nrg1 may modulate dietary effects. PMID: 31284014 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Publication date: Available online 22 August 2019Source: The Lancet PsychiatryAuthor(s): Meng-Chuan Lai, Caroline Kassee, Richard Besney, Sarah Bonato, Laura Hull, William Mandy, Peter Szatmari, Stephanie H AmeisSummaryBackgroundCo-occurring mental health or psychiatric conditions are common in autism, impairing quality of life. Reported prevalences of co-occurring mental health or psychiatric conditions in people with autism range widely. Improved prevalence estimates and identification of moderators are needed to enhance recognition and care, and to guide future research.MethodsIn this systematic review and meta-analysis...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Authors: Fornaro M, Fusco A, Anastasia A, Cattaneo CI, De Berardis D Abstract Introduction:Treatment-resistant depression (TRD), seldom interchangeably referred to as 'depression inadequately responding to the standard antidepressant drug,' carries a significant burden. The atypical antipsychotics represent a popular augmentation strategy for antidepressant-resistant depression, although their efficacy/safety profiles vary across different agents and presentations of depression. Areas covered: This review appraises the evidence supporting the use of brexpiprazole augmentation for major depressive disorder (MDD) adu...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Neuropsychopharmacology, Published online: 24 August 2019; doi:10.1038/s41386-019-0495-4Lessons learned by giving amphetamine to antipsychotic-medicated schizophrenia patients
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
ConclusionThese results confirm the significant association between rs11038167 and rs835784 and rs11038172 polymorphisms and increased risk of schizophrenia in Iranian population suggested earlier in previous studies on Han Chinese population.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 22 August 2019Source: Pharmacological ResearchAuthor(s): Chuanhong Luo, Xiaorong Xu, Xichuan Wei, Wuwen Feng, Haozhou Huang, Haiyan Liu, Runchun Xu, Junzhi Lin, Li Han, Dingkun ZhangAbstractIt is a common phenomenon that people are in a sub-health condition and facing “unexplained fatigue”, which seriously affects their health, work efficiency and quality of life. Meanwhile, fatigue is also a common symptom of many serious diseases such as HIV/AIDS, cancer, and schizophrenia. However, there are still no official recommendations for the treatment of various forms of fatigue. So...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Molecular Psychiatry, Published online: 23 August 2019; doi:10.1038/s41380-019-0492-3Dosage sensitivity intolerance of VIPR2 microduplication is disease causative to manifest schizophrenia-like phenotypes in a novel BAC transgenic mouse model
Source: Molecular Psychiatry - Category: Psychiatry Authors: Source Type: research
AbstractThe aim of the study was to assess rates of severe parkinsonism related to different antipsychotic drugs (APDs) using data from an observational pharmacovigilance programme in German-speaking countries —Arzneimittelsicherheit in der Psychiatrie (AMSP). Data on APD utilization and reports of severe APD-induced parkinsonism were collected in 99 psychiatric hospitals in Austria, Germany and Switzerland during the period 2001–2016. Of 340,099 patients under surveillance, 245,958 patients were trea ted with APDs for the main indications of schizophrenic disorders, depression, mania and organic mental disorde...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
CONCLUSIONS: Some, but not all agents with anti-inflammatory properties showed efficacy. Effective agents were aspirin, estrogens, minocycline, and NAC. We observed greater beneficial results on symptom severity in FEP or early-phase schizophrenia. PMID: 31439071 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Conclusions: In terms of the primary objective, the relatively low dropout rate observed in the present study suggests that SCIT is feasible and well tolerated by patients with schizophrenia in Japan. This view is also supported by participants’ relatively high attendance and intrinsic motivation.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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