Thiosemicarbazone derivatives: Design, synthesis and in vitro antimalarial activity studies.

Thiosemicarbazone derivatives: Design, synthesis and in vitro antimalarial activity studies. Eur J Pharm Sci. 2019 Jul 05;:104986 Authors: Matsa R, Makam P, Kaushik M, Hoti SL, Kannan T Abstract Different types of thiosemicarbazone derivatives were designed and tested for their Drug-Like Molecular (DLM) nature by using Lipinski and Veber rules. Subsequently, compounds with DLM properties were synthesized and characterized by spectral methods. In vitro antimalarial activity studies of the synthesized thiosemicarbazone derivatives have been carried out against Plasmodium falciparum, 3D7 strain using fluorescence assay method and found that the compounds, (E)-2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carbothioamide (6), (E)-2-(1-(3-bromophenyl) ethylidene) hydrazine-1-carbothioamide (15) and (E)-2-(3,4,5-trimethoxybenzylidene) hydrazine-1-carbothioamide (29) showed notable antimalarial activity with EC50 values of 13.54 μM, 15.83 μM and 14.52 μM respectively. PMID: 31283946 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research