Rat intestinal drug permeability: a status report and summary of repeated determinations.

This report showed that the SPIP and ICL methods are important in situ models for understanding and predicting intestinal drug absorption. However, conclusions based on permeability values sourced from different laboratories may not be reliable. Because each permeability study is unique and because between- and even within-laboratory variability can be substantial, data from individual studies should preferably be interpreted separately.
PMID: 31283980 [PubMed - as supplied by publisher]

Source: European Journal of Pharmaceutics and Biopharmaceutics - July 4, 2019 Category: Drugs & Pharmacology Authors: Dubbelboer I, Dahlgren D, Sjögren E, Lennernäs H Tags: Eur J Pharm Biopharm Source Type: research