Neuropeptide FF (FLFQPQRF-NH2) and its Fragments Bind to α2δ Subunit of Voltage-Gated Calcium Channels.

CONCLUSION: FLFQPQRF-NH2, FLFQP-NH2 and FLP-NH2 displace bound gabapentin in membrane preparations of rat cerebral cortex. Binding cooperativity was detected when GBP/FLFQP-NH2/FLP-NH2 were incubated together. These novel binding sites may provide new approaches to modulate L-type Ca2+ channels. PMID: 31287790 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31287790?dopt=Abstract

Source: J Pharm Pharm Sci - July 11, 2019 Category: Drugs & Pharmacology Authors: Skubatz H Tags: J Pharm Pharm Sci Source Type: research