How a Durham firm stands to benefit from an unexpected break in a Japanese trial

Schedule changes in drug development are not uncommon, but one Triangle drug developer is facing an unusual situation: an unexpected stroke of luck that could shorten its drug development by several months.
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Source: BMJ Comments - Category: General Medicine Source Type: forums
In conclusion, this study will provide high-quality data for the decision-making process regarding premedication in elderly surgical patients.Trial,NCT03052660. Registered on 14 February 2017. EudraCT2016-004555-79.
Source: Trials - Category: Research Source Type: clinical trials
AbstractThe oral triiodothyronine for infants and children undergoing cardiopulmonary bypass (OTICC) trial showed that Triiodothyronine (T3) supplementation improved hemodynamic and clinical outcome parameters. We tested the validity of low cardiac output syndrome (LCOS), derived using clinical parameters and laboratory data, by comparing the LCOS diagnosis with objective parameters commonly measured in a cardiac intensive care unit (CCU) setting. OTICC, a randomized, placebo-controlled trial included children younger than 3  years with an Aristotle score between 6 and 9. We used the existing trial data set to compare...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
AbstractAdult neurogenesis in the subventricular zone is a topic of intense research, since it has vast implications for the fundamental understanding of the neurobiology of the brain and its potential to being harnessed for therapy in various neurological disorders. Investigation of adult neurogenesis has been complicated by the difficulties with characterization of neural stem cells in vivo. However, recent single-cell transcriptomic studies provide more detailed information on marker expression in neural stem cells and their neuronal lineage, which hopefully will result in a more unified discussion. Regulation of the mu...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Authors: Olschewski H, Canepa M, Kovacs G Abstract Chronic heart and lung diseases are very common in the elderly population. The combination of chronic heart failure and chronic obstructive pulmonary disease (COPD) is also common and, according to current guidelines, these patients should be treated for both diseases. In patients with heart failure, beta-blockers are very important drugs because their use is associated with significantly improved morbidity and mortality. These beneficial effects were documented in patients with and without COPD, although theoretically there is a risk for bronchoconstriction, parti...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Authors: Zhan X, Yang M, Chen Y, Zhang L, Yan C, Wang Y Abstract Objective: Accumulating evidence has demonstrated that dialysis patients are at increased risk for stroke. However, the impact of dialysis modalities on stroke risk remains controversial. We conducted a systematic review and meta-analysis to determine the effect of peritoneal dialysis (PD) and hemodialysis (HD) on stroke risk. Methods: A systematic search of PubMed, EMBASE, and Web of Science was performed to identify articles comparing the stroke outcomes of dialysis patients. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were extracted...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Conclusion: The risk factors like high TG, low HDL, high BP, and high fasting glucose were found higher particularly in younger population which may lead to diagnosis &complications of diabetes, hypertension and lipid abnormality. Due to changing physiology in young and middle age population these individuals are moving towards metabolic syndrome easily and needs frequent monitoring, preventive checkups, and lifestyle changes to prevent complications.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionsThe mean MPV was statistically significantly higher in the uncontrolled DM group and there was a statistically significant positive correlation between MPV and albuminuria.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 13 July 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): W.S. Harris, K.H. Jackson, J.T. Brenna, J.C. Rodriguez, N.L. Tintle, L. CornishAbstractBackgroundThe Omega-3 Index (O3I; erythrocyte EPA+DHA as a percent of total fatty acids) is inversely related to risk for cardiovascular disease (CVD). The cardioprotective target O3I is 8%-12%. O3I levels in American regions with high CVD risk are poorly characterized.PurposeTo determine the O3I in individuals participating in a Seafood Nutrition Partnership (SNP) survey in seven US cities in the CVD “belt.&rdquo...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
Photo credit Huber Chaland Dear Carol: My dad has been Mom’s caregiver since her stroke ten years ago. Dad’s 79 and healthy except for Type 2 diabetes. I visit my parents every few days to help them out so I set up both of their medications for the week but Dad often leaves the diabetes medication in the pillbox. When I ask him why he says that the medication makes him feel dizzy and sluggish so he hates taking it. I remind him of the possible complications of diabetes but he brushes me off because he’s of normal weight and used to be physically active. That makes no sense since he has diabetes no ma...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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