Hidradenitis Suppurativa Area and Severity Index (HASI): a pilot study to develop a novel instrument to measure the physical signs of hidradenitis suppurativa.
This article is protected by copyright. All rights reserved. PMID: 31286486 [PubMed - as supplied by publisher]
Abstract Circulating concentrations of the split complement factor C5a are significantly increased in hidradenitis suppurativa (HS)1 . C5a exerts strong chemotaxis and activation of neutrophils at the inflammatory areas so that blockade may be a promising therapeutic target. IFX-1 is a monoclonal IgG4 kappa antibody that selectively binds to C5a and blocks its biological activity (data on file at InflaRx). PMID: 31954061 [PubMed - as supplied by publisher]
AbstractHidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severi...
Authors: Collier E, Shi VY, Hsiao JL Abstract Hidradenitis suppurativa (HS) can have devastating impacts on quality of life, especially during adolescence when patients face unique challenges related to self-esteem, body-image and sexual maturation. Many teenage HS patients also experience social challenges related to school, relationships and employment that may require physician intervention. Strategies for comprehensive management of this special group include addressing low medication adherence, screening for comorbidities, and recommending practical lifestyle modifications to reduce disease flares. Herein we r...
Condition: Hidradenitis Suppurativa Interventions: Behavioral: Verbal consultation; Behavioral: Written Action Plan Sponsor: University of Arizona Recruiting
guez Luis F PMID: 31937445 [PubMed - as supplied by publisher]
Severe Hurley stage 1 Hidradenitis suppurativa (HS1) is a difficult to treat form of the disease.
In Reply We thank Adelekun and colleagues for their response to our Editorial calling for accelerated hidradenitis suppurativa (HS) research and improved care of patients with HS. We wholeheartedly agree that more evidence about the effects of HS on fertility, pregnancy, maternal and fetal outcomes, and lactation is needed to help guide optimal care of patients with HS who are of childbearing potential.
To the Editor We read with interest the Editorial by Naik and Lowes and agree that there is an urgent need to advance knowledge in hidradenitis suppurativa (HS). We wish to highlight a particularly vulnerable but overlooked population with HS: those who are pregnant or seeking to become pregnant.
Abstract Hidradenitis suppurativa (acne inversa) is a chronic inflammatory follicular skin disease which leads to fistulae, abscesses and scarring. The Hurley classification is used to quantify the extent of the disease whereby stage III is associated with extensive disfiguring lesions. The most frequently used conservative treatment options are topical clindamycin, systemic antibiotics, e.g. clindamycin and rifampicin, anti-TNF antibodies and laser epilation. Complete excision of fistulae with or without plastic coverage of defects are the mainstays of surgical treatment. Preoperative and postoperative ...